著者
Kikuaki Yoshida Ayaka Sakaki Yoriko Matsuyama Toshiki Mushino Masanori Matsumoto Takashi Sonoki Shinobu Tamura
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
vol.61, no.3, pp.407-412, 2022-02-01 (Released:2022-02-01)
参考文献数
28
被引用文献数
1 8

A 57-year-old man without underlying diseases presented with fatigue, loss of appetite, and jaundice 1 week after receiving the first dose of the BNT162b2 mRNA coronavirus disease 2019 (COVID-19) vaccine and showed hemolytic anemia with fragmented erythrocytes and severe thrombocytopenia 2 weeks after receiving the vaccine. An a disintegrin-like and metalloproteinase with thrombospondin type 1 motifs 13 (ADAMTS13) activity level of <10% and ADAMTS13 inhibitor positivity confirmed the diagnosis of acquired thrombotic thrombocytopenic purpura (TTP). Combination therapy with plasma exchange, corticosteroid, and rituximab improved the clinical outcome. We herein report the first Japanese case of TTP possibly associated with vaccination. Physicians should be alert for this rare but life-threatening hematological complication following COVID-19 vaccination.

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外部データベース (DOI)

Twitter (11 users, 11 posts, 14 favorites)

Purpura thrombotique thrombocytopénique acquis après injection de Pfizer Un homme de 57 ans sans maladies sous-jacentes s'est présenté avec de la fatigue, une perte d'appétit et une jaunisse 1 semaine après avoir reçu la première dose de #Pfizer https://t.co/AskekbLNTO
"Acquired Thrombotic Thrombocytopenic Purpura Following BNT162b2 mRNA Coronavirus Disease Vaccination in a Japanese Patient" https://t.co/7dQQm5dDiF
Acquired Thrombotic Thrombocytopenic Purpura Following Pfizer shot A 57-year-old man without underlying diseases presented with fatigue, loss of appetite, and jaundice 1 week after receiving the first dose of #Pfizer https://t.co/BSn3Ayr6Kh

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