著者
Shogo Hanai Mitsunaga Iwata Teruhiko Terasawa
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
pp.2339-18, (Released:2019-06-27)
参考文献数
9
被引用文献数
1

Pivoxil-containing cephalosporins can result in symptomatic hypocarnitinemia in children. We herein report a case of an 85-year-old man at risk of carnitine deficiency who developed relapsing symptomatic hypoglycemia after treatment with cefcapene pivoxil for urinary tract infection. On admission, laboratory tests showed low blood carnitine concentrations with low normal blood ketone levels. The patient was successfully treated by the oral administration of levocarnitine and dietary modification, including aggressive consumption of meat and dairy products, and remained symptom-free for nine months after the correction of carnitine concentrations. Healthcare providers should be cautious when prescribing pivoxil-containing antimicrobials to patients at high risk of hypocarnitinemia.

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尿路感染症に対してセフカペンピボキシル(フロモックス)による治療後に低カルニチン血症からの低血糖を呈した85歳男性の1例(Intern Med 2019 Jun27) https://t.co/Y0S6yk49DZ ピボキシル基をもつ経口第3世代セフェムでの低カルニチン血症は小児しか聞いたことないですが成人でも起こるんですねぇ

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