著者
Kenta Nonomura Katsumi Iizuka Yayoi Kuwabara-Ohmura Daisuke Yabe
出版者
The Japanese Society of Internal Medicine
雑誌
Internal Medicine (ISSN:09182918)
巻号頁・発行日
pp.4323-19, (Released:2020-03-19)
参考文献数
25

A 72-year-old man had type 2 diabetes (T2D) that had been diagnosed at 54 years old. Macroalbuminuria was first detected at age 64. While his HbA1c had been kept below 7%, his estimated glomerular filtration rate (eGFR) was declining rapidly. At 70 years old, his eGFR dropped below 50 ml/min/1.73 m2. A renal biopsy revealed diabetic nephropathy. sodium glucose transporter 2 inhibitors (SGLT2i)/glucagon-like peptide-1 receptor agonists (GLP-1RA) combination therapy substantially improved his eGFR and urinary albumin level, and the renoprotective effect persisted for the two-year study period. These findings suggest that SGLT2i and GLP-1RA can additively improve the renal function in patients with T2D.

言及状況

外部データベース (DOI)

Twitter (2 users, 2 posts, 1 favorites)

腎保護効果の期待されるGLP-1受容体作動薬、SGLT2阻害薬を併用したらどうなるか?そんな疑問に関する症例報告を、当科博士課程の野々村健太医師がまとめてくれました。まとまった検討が圧倒的に不足しており、今後、質の高い臨床研究で解… https://t.co/Y6lux8IJ7U

収集済み URL リスト