著者
Song-Gyu RA Hironari NAKAGAWA Yuki TOMIGA Hiroki IIZAWA Shihoko NAKASHIMA Yasuki HIGAKI Kentaro KAWANAKA
出版者
Center for Academic Publications Japan
雑誌
Journal of Nutritional Science and Vitaminology (ISSN:03014800)
巻号頁・発行日
vol.68, no.4, pp.243-249, 2022-08-31 (Released:2022-08-31)
参考文献数
32

We examined the effects of dietary vitamin D deficiency on markers of mitochondrial biogenesis and dynamics in rat soleus muscle. Male Wistar rats were fed a chow with no vitamin D (No-D; 0 IU/kg) or a moderate dose (Mod-D; 2,000 IU/kg) of vitamin D chow for 8 wk. Compared to the Mod-D group, at 8 wk the No-D group showed significantly lower serum 25(OH)D levels. Although vitamin D deficiency had no effect on body composition, the No-D rats showed significantly decreased levels of PGC-1α, a marker of skeletal muscle mitochondrial biogenesis, and DRP1, a marker of skeletal muscle mitochondrial fission. The change in the PGC-1α protein expression and the serum 25(OH)D concentrations were significantly correlated. The change in DRP1 protein expression and the serum 25(OH)D concentrations tended to be correlated. There was no significant between-group difference in markers of mitochondrial fusion (MFN2 and OPA1) and mitophagy (PARKIN) in soleus muscle, and no relationship with serum 25(OH)D concentrations. Collectively our findings suggest that dietary vitamin D deficiency decreased PGC-1α and DRP1 protein expression in rat soleus muscle.

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This week’s news! Our icons are in Journal of Nutritional Science and Vitaminology! https://t.co/ShpGPg40Uh https://t.co/XsD2JPAcrx Thank you for using our icons!!! #vitaminology #science #icon #science #lab #free #scientist #medical #アイコン #ラボ #lab-icons https://t.co/52BNgQtzIA
La vitamina D tiene una gran importancia en la salud, pero también en el rendimiento. En esta reciente investigación (en ratones) se ha demostrado que un déficit disminuye la biogénesis y marcadores de fisión mitocondrial (PGC-1α y DRP1 respectivamente) https://t.co/tcsfNDSdHc https://t.co/6lYpEv474d
Effects of Dietary Vitamin D Deficiency on Markers of Skeletal Muscle Mitochondrial Biogenesis and Dynamics https://t.co/IhIvh42VJN "Collectively our findings suggest that dietary vitamin D deficiency decreased PGC-1α and DRP1 protein expression in rat soleus muscle."
Effects of Dietary Vitamin D Deficiency on Markers of Skeletal Muscle Mitochondrial Biogenesis and Dynamics (open access) https://t.co/gn9UJHKYwJ #nutrition #diet #VitaminD
アクセプトされた論文が公開されました。Free accessになっていますので興味のある方は覗いてみてください。 https://t.co/AXppOQdtkk ビタミンD欠乏食が骨格筋のミトコンドリアに及ぼす影響を検証しました。 https://t.co/i84LGWSS85
New publication from our team @yuki_tomiga @iizawa_nutri @higaki_lab_fu published in Journal of Nutritional Science and Vitaminology: Effects of Dietary Vitamin D Deficiency on Markers of Skeletal Muscle Mitochondrial Biogenesis and Dynamics https://t.co/AXppOQdtkk

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