In humans, A rare side effect of high daily doses of #rapamycin and everolimus is mild and reversible hyperglycemia due to inhibition of mTORC1 (not mTORC2) thus decreasing insulin production. The same as in prolonged fasting and keto diet, beneficial https://t.co/HX6XnnXS1a

@LammingLab In humans, A rare side effect of High Daily doses of rapamycin and everolimus is mild and reversible hyperglycemia. Its due to inhibition of mTORC1 (not mTORC2) thus decreaseing insulin production. The same as for prolonged fasting and keto diet https://t.co/HX6XnnXS1a

@KenDBerryMD How to decrease insulin levels? #Rapamycin and everolimus, anti-aging drugs, powerful tools to decrease #insulin. At high daily doses, everolimus can be so effective that may cause (in some patients) transient and reversible hyperglycemia https://t.co/HX6XnnXS1a

@KenDBerryMD #Rapamycin and everolimus, mTOR inhibitors and anti-aging drugs, decreases #insulin levels. This may lead to transient and reversible hyperglycemia after several weeks of treatment with high doses. It’s benevolent “side effect” if occurs https://t.co/HX6XnnXS1a

A circadian rhythm-restricted diet regulates autophagy to improve cognitive function and prolong lifespan https://t.co/QEZJ4t3G5b @jstage_ej https://t.co/7CHlx0Vt9t