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Daniel J Drucker (@DanielJDrucker)

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1 0 0 0 OA Acromegaly Cases Exhibiting Increased Growth Hormone Levels during Oral Glucose Loading with Preadministration of Dipeptidyl Peptidase-4 Inhibitor

Acromegaly, GH, GHRH, Dipeptidyl Peptidase-4 and GIP. Some modest interactions https://t.co/iJTPmfJvum

4 0 0 0 OA Suicide attempt by an overdose of sitagliptin, an oral hypoglycemic agent: A case report and a review of the literature

Notably, use of DPP4i as monotherapy was NOT associated with adverse outcomes in the above analysis of “inappropriate dosing’ #T2D There are case reports of (failed) suicide attempts in PPL who ingested DPP4 inhibitors, without #hypoglycemia or toxicity https://t.co/9QmJiS0kib

1 0 0 0 OA Uncovering the role of MAFB in glucagon production and secretion in pancreatic α-cells using a new α-cell-specific Mafb conditional knockout mouse model

"α-cell number but also glucagon production were significantly decreased in MafbΔGcg mice" #islets #diabetes https://t.co/NblOrl25tp

2 0 0 0 OA Effects of Sitagliptin on the Coronary Flow Reserve, Circulating Endothelial Progenitor Cells and Stromal Cell-derived Factor-1alpha

Saturday morning version of The Assay Matters. Here using an ELISA that does not recognize cleaved vs. non-cleaved SDF-1, the authors infer that DPP-4 does not play a role in SDF-1 cleavage https://t.co/zSKt6G1wuR https://t.co/CSpRBOGHUp

3 0 0 0 OA Identification of plasma binding proteins for glucose-dependent insulinotropic polypeptide

A sticky situation for GIP. Identification of plasma binding proteins albumin, IgG and transferrin, three proteins highly abundant in the human peripheral circulation, for glucose-dependent insulinotropic polypeptide https://t.co/mncZNLDQsC

2 0 0 0 OA Linagliptin protects rat carotid artery from balloon injury and activates the NRF2 antioxidant pathway

DPP-4 inhibitors-generally cardioprotective/vasoprotective in preclinical studies-Safe but no reduction of MACE events in human CVOTs #T2D https://t.co/4vGZJffkoy

2 0 0 0 OA Analysis of the Correlation between the Myocardial Expression of DPP-4 and the Clinical Parameters of Patients with Heart Failure

Analysis of the Correlation between the Myocardial Expression of DPP-4 and the Clinical Parameters of Patients with #HeartFailure https://t.co/ZMwRA3XH5N

1 0 0 0 OA Blackcurrant Extract Ameliorates Hyperglycemia in Type 2 Diabetic Mice in Association with Increased Basal Secretion of Glucagon-Like Peptide-1 and Activation of AMP-Activated Protein Kinase

Jammin up L cell GLP-1 Secretion With Blackcurrant Extract And Activation of AMP-Activated Protein Kinase https://t.co/0UndRYiHHl

1 0 0 0 OA Effect of Sitagliptin on Coronary Flow Reserve Assessed by Magnetic Resonance Imaging in Type 2 Diabetic Patients With Coronary Artery Disease

No Effect of Sitagliptin on Coronary Flow Reserve in Subjects #T2D #HeartDisease #CAD https://t.co/jk3hphl4ZK