Daniel J Drucker (@DanielJDrucker)

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Notably, use of DPP4i as monotherapy was NOT associated with adverse outcomes in the above analysis of “inappropriate dosing’ #T2D There are case reports of (failed) suicide attempts in PPL who ingested DPP4 inhibitors, without #hypoglycemia or toxicity https://t.co/9QmJiS0kib
"α-cell number but also glucagon production were significantly decreased in MafbΔGcg mice" #islets #diabetes https://t.co/NblOrl25tp
Saturday morning version of The Assay Matters. Here using an ELISA that does not recognize cleaved vs. non-cleaved SDF-1, the authors infer that DPP-4 does not play a role in SDF-1 cleavage https://t.co/zSKt6G1wuR https://t.co/CSpRBOGHUp
A sticky situation for GIP. Identification of plasma binding proteins albumin, IgG and transferrin, three proteins highly abundant in the human peripheral circulation, for glucose-dependent insulinotropic polypeptide https://t.co/mncZNLDQsC
DPP-4 inhibitors-generally cardioprotective/vasoprotective in preclinical studies-Safe but no reduction of MACE events in human CVOTs #T2D https://t.co/4vGZJffkoy
Analysis of the Correlation between the Myocardial Expression of DPP-4 and the Clinical Parameters of Patients with #HeartFailure https://t.co/ZMwRA3XH5N
No Effect of Sitagliptin on Coronary Flow Reserve in Subjects #T2D #HeartDisease #CAD https://t.co/jk3hphl4ZK

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