Dr. Endo reported "compactin" as a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase. This enzyme regulates the rate-limiting step in cholesterol biosynthesis. https://t.co/wwkSugXrRc https://t.co/dkq67o2PNh 10/
His initial reports were all published during WWI, thus his discovery became known late in Europe. This was the first experimental model of chemical carcinogenesis on rabbit ears based on human pathology. https://t.co/Tbz0nAQGIQ https://t.co/uKsTQdGaHd 8/
In 1914, the pair reported the appearance of a neoplasm akin to a malignant growth after 112 days of coal tar application on rabbit ears. This work sparked much criticism, as previous similar efforts had all failed. https://t.co/5iaShs0j58 7/