The involvement of progranulin (PGRN) for α-Synuclein reduction through autolysosome formation; Intracerebroventricular administration of PGRN rescues MPTP & 6-OHDA models of #Parkinsons; PGRN also⬆️in α-Syn degradation (via the autophagy-lysosome pathway) https://t.co/0p1ZAmzg9x https://t.co/z0uqbTa5X8

Nrf2 expression is decreased in brains of transgenic mice carrying #Parkinsons-associated LRRK2 variant; Also in LRRK2 overexpressing SH-SY5Y cells https://t.co/FPnCJCGpHF https://t.co/gFFNlJIgxw

Inhibition of #Parkinsons-associated LRRK2 ameliorates dexamethasone-induced glucose intolerance (by preventing impairment in GLUT4 membrane translocation in adipocytes) https://t.co/Yvkh3HZHKq https://t.co/4Z8rh9kCPg

New data suggsts that macrophage migration inhibitory factor (MIF) can be S-nitrosylated by a physiological nitric oxide donor, preventing induction of BDNF expression. Implications for #Parkinsons & #Alzheimers? https://t.co/eM7QlYmfTe https://t.co/tqshnZQVov

Interesting: Chinese researchers report that a genetic variant (rs823114) in the NUCKS1 gene decreases risk of developing #Parkinsons & shows a male genetic distribution bias in the Han Chinese population https://t.co/g1OyEpft31 https://t.co/cEurzItMo9

Interesting: 10% of people with sporadic #Parkinson’s lack one copy of the midnolin gene. Transcriptome analysis reveals that Midnolin regulates mRNA levels of several Parkinson’s associated/causative genes, including Parkin & alpha synuclein https://t.co/wZoXfqrHXH https://t.co/hiIAsBM8gG