著者
TOYAMA J. HONJO HARUO OSAKA TOSHIYUKI ANNO TAKAFUMI HIRAI MAKOTO OHTA TOSHIKI KODAMA ITSUO YAMADA KAZUO
出版者
社団法人日本循環器学会
雑誌
Jpn. Circ. J. (ISSN:00471828)
巻号頁・発行日
vol.51, pp.163-171, 1987
被引用文献数
1

In order to clarify the role of Purkinje fibers in the occurrence of reperfusion arrhythmias, endocardial mapping was performed on perfused canine hearts by attaching 42 close bipolar electrodes to the endocardial surface of the left ventricular septum. Reperfusion with oxygenated Krebs-Ringer solution following 30 min of coronary occulusion induced ventricular tachycardia (VT) in 14 out of 23 preparations. These VT degenerated into ventricular fibrillation (VF) within 1 min after the reperfusion in all but 3 cases. Endocardial mapping revealed that the excitations during VT were always initiated by the Purkinje activities and that myocardial excitations were expanded in a centrifugal manner through Purkinje-muscle junctional area. Furthermore, this excitation pattern was preserved, in the early phase of VT, even though the propagation pattern was distorted. VF was always induced by reperfusion following 30 min of ischemic condition, that is, coronary perfusion with a hyperkalemic (K=10 mM), acidic (pH=6.8) and hypoxic (PO_2=20-40 mmHg) solution (4/4 cases). Elimination of hyperkalemia from the ischemic condition markedly prevented occurrence of VF (1/6 cases) during reperfusion but it did not affect occurrence of VT (4/6 cases); this implies that hyperkalemia causes the onset of VF but has less effect on the occurrence of VT. It has been separately confirmed by micro-electrode experiment, using the dissected papillary muscle of the canine right ventricle, that abnormal impulse formation during re-oxygenation was triggered in Purkinje fibers around Purkinje-muscle junction.

言及状況

Twitter (1 users, 1 posts, 0 favorites)

こんな論文どうですか? Endocardial exciation and conduction during reperfusion arrhythmias(TOYAMA J.ほか),1987 https://t.co/DQOse2QgMh

収集済み URL リスト