著者

Minagawa Nobuko Meguro Keiichi Sakajo Shigeru Yoshimoto Akio

出版者

社団法人日本農芸化学会

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.58, no.7, pp.1334-1335, 1994-07-23

被引用文献数

7 13

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An antitumor antibiotic, ascofuranone, selectively inhibited succinate- and NADPH-dependent O_2 uptake activity of the mito-chondria from Hansenula anomala, suggesting its interaction with the ubiquinone-reduction site of succinate dehydrogenase and external NADPH-dehydrogenase reactions. The action of ascofur-anone on the mitochondria is clearly different from that of antimycin A, the Q_i site inhibitor.