- 著者
- Minagawa Nobuko Meguro Keiichi Sakajo Shigeru Yoshimoto Akio
- 出版者
- 社団法人日本農芸化学会
- 雑誌
- Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)
- 巻号頁・発行日
- vol.58, no.7, pp.1334-1335, 1994-07-23
- 被引用文献数
- 7 13
An antitumor antibiotic, ascofuranone, selectively inhibited succinate- and NADPH-dependent O_2 uptake activity of the mito-chondria from Hansenula anomala, suggesting its interaction with the ubiquinone-reduction site of succinate dehydrogenase and external NADPH-dehydrogenase reactions. The action of ascofur-anone on the mitochondria is clearly different from that of antimycin A, the Q_i site inhibitor.