著者

西部 三省 木下 英弘 武田 秀勝 岡野 五郎

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.38, no.6, pp.1763-1765, 1990-06-25

被引用文献数

16

---

Ten phenolic compounds, isofraxidin (1), (+)-syringaresinol-di-O-β-D-glucoside (2), syringin (3), chlorogenic acid (4), isofraxidin-7-O-β-D-glucoside (5), 2,6-dimethoxy-p-benzoquinone (6), (+)-pinoresinol-O-β-D-glucoside (7), (+)-syringaresinol-O-β-D-glucoside (8), (+)-pinoresinol-di-O-β-D-glucoside (9), and (+)-medioresinol-di-O-β-D-glucoside (10), were isolated from the stem bark of Acanthopanax senticosus HARMS and identified, respectively.The aquenous extract of the stem bark exhibited a prolonging effect on the exercise time to exhaustion in chronic swimming stressed rats. The effect on the exercise time in the chronic swimming stressed rats was respectively tested for compounds 2 and 4,which are major constituents of the stem bark. As a result, it was indicated that compound 2 is the compound responsible for part of the pharmacological effect which the aqueous extract of the stem bark showed.