Azole Series. II. Reactions of 2-Acylamino-2-cyanoacetamides leading to 5-Acylaminooxazole-4-carboxamides and to Oxazolo [5,4-d] pyrimidines

1 0 0 0 Azole Series. II. Reactions of 2-Acylamino-2-cyanoacetamides leading to 5-Acylaminooxazole-4-carboxamides and to Oxazolo [5,4-d] pyrimidines

著者: 関屋実鈴木次郎柿谷芳宏
出版者: 公益社団法人日本薬学会
雑誌: Chemical & pharmaceutical bulletin (ISSN:00092363)
巻号頁・発行日: vol.18, no.6, pp.1233-1238, 1970-06-25

Reaction for preparation of a new series of 5-acylaminooxazole-4-carboxamides has been found. 5-Acetamidooxazole-4-carboxamides were obtained by heating 2-acylamino-2-cyanoacetamides with acetic anhydride in the presence of perchloric acid. Analogous 5-form-amido derivatives were also obtained by heating the same substrates with a mixture of formic acid and acetic anhydride in the presence of hydrochloric acid. Trials for synthesis of oxazolo [5,4-d] pyrimidine-7-ol from the 5-acylaminooxazole-4-carboxamide obtained were also successful in some cases by means of heating with potassium bicarbonate solution.

2013-12-10 20:30:09
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こんな論文どうですか？ Azole Series. II. Reactions of 2-Acylamino-2-cyanoacetamides leading to 5-Acylam(関屋実ほか),1970 http://t.co/B9wnlx7hsL

こんな論文どうですか？ Azole Series. II. Reactions of 2-Acylamino-2-cyanoacetamides leading to 5-Acylam(関屋実ほか),1970 http://t.co/OZzSdDSEAG

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