著者
Nawawi As'ari Ma Chao-mei Nakamura Norio HATTORI Masao KUROKAWA Masahiko SHIRAKI Kimiyasu KASHIWABA Noriaki ONO Minoru
出版者
公益社団法人日本薬学会
雑誌
Biological & pharmaceutical bulletin (ISSN:09186158)
巻号頁・発行日
vol.22, no.3, pp.268-274, 1999-03-15
被引用文献数
3 34

By screening water and MeOH extracts of 30 Chinese medicinal plants for their anti-herpes simplex virus (HSV)-1 activity, a MeOH extract of the root tubers of Stephania cepharantha HAYATA showed the most potent activity on the plaque reduction assay with an IC_<50> value of 18.0 μg/ml. Of 49 alkaloids isolated from the MeOH extract, 17 alkaloids were found to be active against HSV-1,including 13 bisbenzylisoquinoline, 1 protoberberine, 2 morphinane and 1 proaporphine alkaloids, while benzylisoquinoline and hasubanane alkaloids were inactive. Although N-methylcrotsparine was active against HSV-1,as well as HSV-1 thymidine kinase deficient (acyclovir resistant type, HSV-1 TK^-)and HSV-2 (IC_<50> values of 8.3,7.7 and 6.7 μg/ml, respectively), it was cytotoxic. FK-3000 was found to be the most active against HSV-1,HSV-1 TK^- and HSV-2 (IC_<50> values of 7.8,9.9 and 8.7 μg/ml) with in vitro therapeutic indices of 90,71 and 81,respectively. FK-3000 was found to be a promising candidate as an anti-HSV agent against HSV-1,acyclovir (ACV) resistant-type HSV-1 and HSV-2.

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こんな論文どうですか? Anti-Herpes Simplex Virus Activity of Alkaloids Isolated from Stephania cepharan(NAWAWI As'ariほか),1999 http://t.co/zb0KTF8O

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