著者

杉原 明

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.86, no.4, pp.349-352, 1966-04-25

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It was found that 2-[2-(5-nitro-2-furyl) vinyl]-5-amino-1,3,4-oxadiazole (II) is obtained by the reaction of thiosemicarbazide with 3-(5-nitro-2-furyl) acryloyl chloride in excess pyridine and by refluxing 5-nitro-2-furanacrylic acid hydrazide with potassium thiocyanate in aqueous hydrochloric acid. 2,2-Disubstituted 3-acetyl-5-[2-(5-nitro-2-furyl) vinyl]-1,3,4-oxadiazolines (VIa〜c) were prepared by refluxing alkanone 5-nitro-2-furanacrylic acid hydrazones with acetic anhydride. Antimicrobial activities of these nitrofuran compounds are presented in Table III.