著者

末宗 洋 原部 哲治 謝 卓峰 酒井 浄

出版者

公益社団法人日本薬学会

雑誌

Chemical & pharmaceutical bulletin (ISSN:00092363)

巻号頁・発行日

vol.36, no.11, pp.4337-4344, 1988-11-25

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Asymmetric hydrolysis of 2,2-bis(acetoxymethyl)cyclopentanone (5) using biocatalysis and its application to a formal synthesis of (-)-melyngolide are described. For the asymmetric induction at the quanternary carbon of 5,cholinesterase from electric eel was found to be effective to afford the (+)-monoacetate (6) (90%ee). Compound (+)-6 was easily converted to the synthetic intermediate (28) for (-)-malyngolide.