- 著者
- 末宗 洋 原部 哲治 酒井 浄
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.36, no.9, pp.3632-3637, 1988-09-25 (Released:2008-03-31)
- 参考文献数
- 10
- 被引用文献数
- 23 30
Two trihydroxy unsaturated C-18 fatty acids [(9S, 12S, 13S)-trihydroxyoctadeca-10E, 15Z-dienoic acid (methyl ester) and (9S, 12S, 13S)-trihydroxy-10E-octadecenoic acid (methyl ester)] isolated from rice plants as agents with activity against blast disease were synthesized from (+)-dimethyl tartrate.
- 著者
- 末宗 洋 原部 哲治 謝 卓峰 酒井 浄
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- Chemical & pharmaceutical bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.36, no.11, pp.4337-4344, 1988-11-25
Asymmetric hydrolysis of 2,2-bis(acetoxymethyl)cyclopentanone (5) using biocatalysis and its application to a formal synthesis of (-)-melyngolide are described. For the asymmetric induction at the quanternary carbon of 5,cholinesterase from electric eel was found to be effective to afford the (+)-monoacetate (6) (90%ee). Compound (+)-6 was easily converted to the synthetic intermediate (28) for (-)-malyngolide.
- 著者
- 末宗 洋 原部 哲治 酒井 浄
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- Chemical & pharmaceutical bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.36, no.9, pp.3632-3637, 1988-09-25
Two trihydroxy unsaturated C-18 fatty acids [(9S, 12S, 13S)-trihydroxyoctadeca-10E, 15Z-dienoic acid (methyl ester) and (9S, 12S, 13S)-trihydroxy-10E-octadecenoic acid (methyl ester)] isolated from rice plants as agents with activity against blast disease were synthesized from (+)-dimethyl tartrate.