- 著者
-
Sasaki Hideki
Akiyama Hiroshi
Yoshida Yoshifumi
KONDO Kazunari
AMAKURA Yoshiaki
KASAHARA Yoshimasa
MAITANI Tamio
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- Biological & pharmaceutical bulletin (ISSN:09186158)
- 巻号頁・発行日
- vol.29, no.12, pp.2514-2518, 2006-12-01
- 被引用文献数
-
4
20
In autumn 2004, many Japanese patients with renal failure developed cryptogenic encephalopathy by consuming sugihiratake mushroom, a Japanese delicacy. To elucidate the relationship between the cryptogenic cases and this mushroom, we conducted a multivariate analysis of metabolites in 'Probably Toxic' sugihiratake collected from the area of encephalopathy outbreaks, and 'Probably Safe' sugihiratake collected from unaffected areas using UPLC/ToF MS. The results indicate that the presence of milligram quantities of vitamin D-like compounds per 10g of dried sugihiratake from the areas of encephalopathy outbreaks. Two hypotheses to induce the encephalopathy are proposed: the found metabolites are (1) vitamin D agonists, which induce acute and severe hypercalcemia and/or hyperammonemia and/or vitamin D toxicity, or (2) vitamin D antagonists, which induce acute and severe hypocalcemia.