著者
中島 恵美 横川 弘一 市村 藤雄 倉田 孝一 木戸 日出喜 山口 成良 山名 月中
出版者
公益社団法人日本薬学会
雑誌
Chemical & pharmaceutical bulletin (ISSN:00092363)
巻号頁・発行日
vol.35, no.2, pp.718-725, 1987-02-25
被引用文献数
4

The disposition characteristics of biperiden were investigated in rats, rabbits, beagles, and humans, and a physiologically based pharmacokinetic model was established by using the hepatic intrinsic clearance of unbound drug concentration and the tissue-to-plasma unbound concentration ratios. Protein-binding parameters and blood-to-plasma concentration ratios were determined, and linear parameters were obtained in beagles and humans over a wide concentration range. The hepatic intrinsic clearance of humans was predicted from the animal data. The coincidence of each tissue-to-plasma Unbound concentration ratio between rats and rabbits was confirmed in the steady state, and the mean tissue-to-plasma unbound concentration ratios were used for the prediction of the plasma concentration-time courses of beagles and humans. The predicted lines fitted the observed plasma concentrations of beagles and a patient well after a single intravenous injection and repeated intramuscular administrations, respectively.

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こんな論文どうですか? A Physiologically Based Pharmacokinetic Model for Biperiden in Animals and Its E(中島 恵美ほか),1987 http://t.co/4XA2EGRRKw
こんな論文どうですか? A Physiologically Based Pharmacokinetic Model for Biperiden in Animals, http://ci.nii.ac.jp/naid/110006280959 The disposition ch

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