著者

矢原 正治 金城 順英 下川 隆志 野原 稔弘 山原 條二 千坂 武司

出版者

天然有機化合物討論会

雑誌

天然有機化合物討論会講演要旨集

巻号頁・発行日

no.27, pp.726-733, 1985-09-07

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We have examined the constituents of three crude drugs showing an antihypercholesteremic activity. 1) Daemonorops draco --- D-7 was obtained as an active substance. It was further separated into two compounds (D-7-I,II) being the isomers each other and their substances were deduced to be the deoxy-proanthocyanidins by the spectral data. 2) Caesalpinia sappan --- Total nineteen compounds relating to brazilin were isolated and the chemical structures of fourteen compounds among them were discussed by the spectroscopic means. SO-k, g,e were the 3-benzyl-chroman-4-one derivatives; SO-i,b,c were shown to be the first examples of the 3-benzyl-chroman-4-ol derivatives and assumed to be the key-intermediates on the biogenetic route of brazilin; All of SO-j,p,SLC-b,c,d presented new novel framework-models among the naturally occurring compounds. SO-j was suggested to be produced from SO-i,b,c by oxidative coupling, SO-p was presumed to be derived from brazilin by oxidative fission. SLC-b,c,d were considered to be originated from brazilin. SLC-b was effective for antihypercholesteremia. 3) Dalbergia odorifera --- Five aromatic compounds, DO-I-V, were isolated from the active fraction and their structures were revealed to be the unique bi-isoflavanoids by the various spectral data.