著者

嶋田 博

出版者

千葉大学

雑誌

千葉医学会雑誌 (ISSN:00093459)

巻号頁・発行日

vol.31, no.5, pp.621-628, 1956-01

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Part I. The left lung of matured rabbits are extirpated, and the residual right lung are histopathologically examined at the first to nineteenth week revealing the following results: In the early stage, physiological emphysema and engorgement appear predominant in the morphologic picture of the residual lungs, however, after the nineth week engorgement becomes gradually go away and develop into proliferation of elastic, argyrophile and collagen fibre in some of the alveolar septa. In the cases killed after the twelfth week new growth rather than dilatation of alveolum is markedly observed. The other group of the rabbits thus (left side, totally) pneumonektomized are also given intravenously by a saline solution suspended with one mg of tubercle bacilli (high virulent, human type) per one cc and one kg body weight in dose from immediately after this operation to the twelfth week. The animals are killed four weeks after this single injection. Histopathological examination reveals that there are rather few tuberculous lesions in the residual lung and spleen, but often plenty in liver. Part II. The rabbits are killed four to twenty weeks after splenectomy and autopsied. In this series liver cells often appear swollen and lucid like vegetable cells, and lymphocytic infiltration and duplication of bile ducts of mild grade is also proved in the Glisson's sheath. Beyond the auther's expection, however, the Kupffer's stellate cells never show hypertrophy or proliferation but even regressive degressive degeneration in some cases. The rabbits get a single, intravenous injection of a solution suspended with the same dose oftubercle bacilli three days to twelve weeks after splenectomy and then four weeks later they are killed. In this series the tuberculous lesions in liver show more marked than those in lungs, or on the contrary there are not so much the specific tuberculous lesions in liver although duplication of bile ducts and infiltration of lymphocytes is so prominent. Part III The rabbits are killed at the different stby only the remained part, and also develop the morphologic and functionologic changes in the other certain organs.