著者

石橋 雄弥 浅野 豪文 上杉 薫 森島 圭祐

出版者

一般社団法人 日本機械学会

雑誌

ロボティクス・メカトロニクス講演会講演概要集

巻号頁・発行日

vol.2015, pp._1P1-O02_1-_1P1-O02_2, 2015

---

In this paper, to improve the spatiotemporal resolution and to reduce the invasiveness, we genetically introduce Optically-Manipulated molecular switch, channelrhodopsin (ChR), into sarcoplasmic reticulum (SR) of C2C12 myoblast, mouse muscle cell lines. A myotube inserted with SR-targeted ChR can respond rapidlier than a myotube inserted with non-targeted ChR for 10-20 ms. A myotube inserted with SR-targeted ChR can contraction only by intracellular ion transportation. We can control intracellular Ca^<2+> ion of the myotube. This technique could facilitate the studies on the myogenesis, the stem cell therapy for muscular disorder, and the bioengineering using the muscle-powered actuator.