Generally, the repositioning and fixation of fragments in the treatment of jaw fractures is performed based on proper occlusion conditions of the upper and lower jaws. However, the treatment of fractures of the mentally and physically handicapped pose a number of problems caused by lack of patient comprehension and cooperation. In this paper, we present two cases of mandibular fracture of handicapped patients, whose closed reduction and fixation was impossible. In these cases, open reduction and ridged fixation of fragments was carried out with screw and plate without intermaxillary fixation. Problems of the treatment of jaw fracture of mentally and physically handicapped patients were discussed.