著者
Iwami Shingo Sato Kei Morita Satoru Inaba Hisashi Kobayashi Tomoko Takeuchi Junko S. Kimura Yuichi Misawa Naoko Ren Fengrong Iwasa Yoh Aihara Kazuyuki Koyanagi Yoshio
出版者
Nature Publishing Group
雑誌
Scientific Reports (ISSN:20452322)
巻号頁・発行日
vol.5, 2015-07-17
被引用文献数
14

Among the four groups of HIV-1 (M ,N, O, and P), HIV-1M alone is pandemic and has rapidly expanded across the world. However, why HIV-1M has caused a devastating pandemic while the other groups remain contained is unclear. Interestingly, only HIV-1M Vpu, a viral protein, can robustly counteract human tetherin, which tethers budding virions. Therefore, we hypothesize that this property of HIV-1M Vpu facilitates human-to-human viral transmission. Adopting a multilayered experimental-mathematical approach, we demonstrate that HIV-1M Vpu confers a 2.38-fold increase in the prevalence of HIV-1 transmission. When Vpu activity is lost, protected human populations emerge (i.e., intrinsic herd immunity develops) through the anti-viral effect of tetherin. We also reveal that all Vpus of transmitted/founder HIV-1M viruses maintain anti-tetherin activity. These findings indicate that tetherin plays the role of a host restriction factor, providing 'intrinsic herd immunity', whereas Vpu has evolved in HIV-1M as a tetherin antagonist.

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こんな論文どうですか? Pandemic HIV-1 Vpu overcomes intrinsic herd immunity mediated by tetherin(Iwami Shingoほか),2015 … https://t.co/fv7zARyE28

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