- 著者
- Iwami Shingo Sato Kei Morita Satoru Inaba Hisashi Kobayashi Tomoko Takeuchi Junko S. Kimura Yuichi Misawa Naoko Ren Fengrong Iwasa Yoh Aihara Kazuyuki Koyanagi Yoshio
- 出版者
- Nature Publishing Group
- 雑誌
- Scientific Reports (ISSN:20452322)
- 巻号頁・発行日
- vol.5, 2015-07-17
- 被引用文献数
- 14
Among the four groups of HIV-1 (M ,N, O, and P), HIV-1M alone is pandemic and has rapidly expanded across the world. However, why HIV-1M has caused a devastating pandemic while the other groups remain contained is unclear. Interestingly, only HIV-1M Vpu, a viral protein, can robustly counteract human tetherin, which tethers budding virions. Therefore, we hypothesize that this property of HIV-1M Vpu facilitates human-to-human viral transmission. Adopting a multilayered experimental-mathematical approach, we demonstrate that HIV-1M Vpu confers a 2.38-fold increase in the prevalence of HIV-1 transmission. When Vpu activity is lost, protected human populations emerge (i.e., intrinsic herd immunity develops) through the anti-viral effect of tetherin. We also reveal that all Vpus of transmitted/founder HIV-1M viruses maintain anti-tetherin activity. These findings indicate that tetherin plays the role of a host restriction factor, providing 'intrinsic herd immunity', whereas Vpu has evolved in HIV-1M as a tetherin antagonist.
- 著者
- Aihara Ikkyu Mizumoto Takeshi Otsuka Takuma Awano Hiromitsu Nagira Kohei Okuno Hiroshi G Aihara Kazuyuki
- 出版者
- Nature Publishing Group
- 雑誌
- Scientific reports (ISSN:20452322)
- 巻号頁・発行日
- vol.4, 2014-01-27
- 被引用文献数
- 53
カエルの合唱の法則を数学と光計測を使って発見. 京都大学プレスリリース. 2014-01-27.
- 著者
- Suetani Hiromichi Iba Yukito Aihara Kazuyuki
- 出版者
- Published for the Yukawa Institute for Theoretical Physics and the Physical Society of Japan
- 雑誌
- Progress of theoretical physics. Supplement (ISSN:03759687)
- 巻号頁・発行日
- no.161, pp.340-343, 2006-04-20
- 参考文献数
- 11
- 被引用文献数
- 1
An approach based on the kernel methods for capturing the nonlinear interdependence between two signals is introduced. It is demonstrated that the proposed approach is useful for characterizing generalized synchronization with a successful simple example. An attempt to choose an optimal kernel parameter based on cross validation is also discussed.