著者

内野 碩

出版者

日本衛生学会

雑誌

日本衛生学雑誌 (ISSN:00215082)

巻号頁・発行日

vol.30, no.3, pp.397-403, 1975

被引用文献数

3

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In the previous papers, the author has clarified that excessive intake of S-methylcysteine sulfoxide (methiin) extracted from cabbage caused splenic hypertrophy and anemia. The present study was undertaken in order to clarify these effects of methiin on rats fed a low protein, high protein or commercial diet.<BR>(I) Male Wistar rats were separated into six groups and the following six different diet were given. Group A: a low protein (6% casein) diet, group B: low protein supplemented with 4% methiin, group C: normal protein (12% casein), group D: normal protein supplemented with 4% methiin, group E: high protein (18% casein), group F: high protein supplemented with 4% methiin. After 35 days, the rats werr sacrificed and various analyses were carried out. Red blood cell counts, hemoglobin and hematocrit in blood decreased and splenic weight and iron levels in spleen and liver increased in the methiin-supplemented groups B, D and F.<BR>(II) Male Wistar rats were separated into five groups and the following five different diets were given for 50 days. Group A: a synthetic diet (15% casein), group B: synthetic diet supplemented with 2% methiin, group C: commercial diet (Oriental Co., MF), group D: commercial deit supplemented with 1% methiin, group E: commercial diet supplemented with 2% methiin. The data revealed that symptoms of anemia and splenic hypertrophy were seen also in rats fed a methiin supplemented commercial diet as well as rats fed a methiin supplemented synthetic diet.