著者

吉田 尚

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.35, no.1, pp.57-63,13, 1959

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Changes in 17-0H-corticosterone and corticosterone levels were determined in the adrenal venous blood of a dog following splanchnic nerve stimulation and ACTH injection, using Bush's system of paper chromatography.<BR>According to my experiments, splanchnic nerve stimulation facilitated the action of ACTH on adrenals to produce 17-0H-corticosterone. While ACTH increased the secretion of both 17-0H-corticosterone and corticosterone, the splanchnic stimulation increased only 17-0H-corticosterone resulting in a marked increase in F/B ratio.<BR>This would suggest a dual control mechanism of adrenal cortical secretion. One, basic 17-OH-corticosterone secretion controled only through ACTH, and the other "extrasecretion" controled through both ACTH and splanchnic nerve impulse produced under stress or sympathicotonic condition of the animal.