著者
石突 吉持 山内 一征 三浦 義孝
出版者
一般社団法人 日本内分泌学会
雑誌
日本内分泌学会雑誌 (ISSN:00290661)
巻号頁・発行日
vol.65, no.2, pp.91-98, 1989-02-20 (Released:2012-09-24)
参考文献数
14
被引用文献数
4 6 2

日本では, 昆布ヨードの過剰摂取による甲状腺中毒症 (ITT) の報告がない。我々は, 日本人が好んで摂取する昆布の過剰摂取がITTを発症させることを見出した。献立表から算出したヨード量28-140mg/日を毎日摂取し, 1ケ月, 1年を経て甲状腺中毒症を示した42, 59歳の女性例である。両例のT3は高く, T3/T4比, T4/γ-T3比は低く, 無機ヨード値は正常生活者の平均2.05ug/dlの+2SDより高値であった。昆布摂取の禁止後, 1ケ月で中毒症状消失, T4, T3, γ-T3, T4/γ-T3比は正常化した。摂取ヨード源を明らかにするため, 昆布内及び水浸昆布の出汁中ヨード量を測定した。昆布内ヨードの99%が水浸30分, 煮沸15分で水溶液中に出る事を確かめた。以上の結果は, ITTが昆布及び昆布出汁の過剰摂取により発症すること, また, 昆布出汁として1日28mg/日以上のヨード量を毎日摂取すると, 日本人ではITTが引き起こされる可能性があることを示唆している。
著者
眞野 弘一
出版者
一般社団法人 日本内分泌学会
雑誌
日本内分泌学会雑誌 (ISSN:00290661)
巻号頁・発行日
vol.26, no.5-6, pp.63-72, 1950-09-20 (Released:2012-09-24)
参考文献数
15

I have tried to examine the criminal from the endocrine standpoint and will give an outline of statistial consideration by wry of the 1st report on the observation with regards to the testicle-size and criminal-quality in addition to the observation of the secondary sexual signs.As the testicle-length-distance from up end to down end, the testicte-thickness-from back edge to front edge, the testicle-width-from right side to left side, when it is measured by the gleitzirkel of the “Martin's type” with an attention not to bring any pressure upon the testicle, keeping by hand the scrotum tense and fixed. Moreover, the inmates were divided into two classes according to the matured signs or the secondary sexual signs of the persons at the adolescense by the intuitive method.1,505 healthy inmates of ages ranging from 16 to 65 were used as tire objective who were grouped according to the legal classification, with a special consideration of means, action, motive or cause, simpleness or habitualness, strong or weak will about their crimes and also the terms of penalty were referred to.The matured-degree from the frequency distribution of the secondary sexual matured sign or the growing-degree of these persons of 16 to 25 years was shown by an expression. By that, it seemed to me that both the testicle-size and the growing-degree have a tendency of increasing little by little up to about 20 years of age and they showed an incomplete possitive correlation(korrelationskoefficient r=0.28)till some 26 years old, showed an incomplete negative correlation(r=-0.22)for persons from 39 to 50 years old, whose testicle-sizes decreased more or less as far as testicles and ages are concerned. The decline is smallest in the case of persons of 51 to 55 comparing with younger people, but the testicle-size increased and showed the adult-size in persons of 60 to 65 again.The testicle-sizes obtained are as follows;It is found that the testicle-size increase in order of each group of criminals of the fraud. the larceny, and the vicious offenders.Of the vicious offenders, the quasi-robbers have the smallest testicles than the others (37.12×26.92×22.20mm 22.16cc) and the size of their terticles is almost the same of the fraud-offenders. On the contrary, the size of the testicles of the robbers made up of principal offendersa( 39.71×29.27×23.60mm 27.45cc) is the biggest among various criminals, and also the murder, rape, arson-offenders have relatively larger testicles. It is found that there seems to be material difference in the size of testicle between the the first offender and the habitual offender.The exactness of the mean calculated according to M ± 3m showed the sphere of locomotion of 033-0.54 for the criminal-adults, with 0.56-0.78 for vicious offenders, 0.54-0.78 for the larceney-offenders. It can be regarded as a genuine arithmetic mean. The fraud offenders have moderate exactness with the sphere of 0.90-2.70 in the average for 5 diameters.If one compares the mean by way of M1-M2/√m21+m22, there is a significance among the three groups as far as the length is concerned ; in the thickness, there is it between the vicious and fraud offenders, and between the fraud and larceny offenders and in the width there is it between the vicious and fraud offenders. There is also a significance between ages except certain ages.Summarizing these results, I have found that there seems to be some meaning between the so-called “Masuline” and testicle-size, and also between the endocrine function and size of testicle.
著者
遠藤 哲夫 佐藤 方信 吉田 博 矢川 寛一
出版者
一般社団法人 日本内分泌学会
雑誌
日本内分泌学会雑誌 (ISSN:00290661)
巻号頁・発行日
vol.54, no.9, pp.1007-1015, 1978-09-20 (Released:2012-09-24)
参考文献数
22

A total of 747 cases of malignant neoplasms of the thyroid reported in the “Annual of the Pathological Autopsy Cases in Japan” during the past 5 years (1969-1973) were reviewed and statistically analysed.Histological diagnosis in this series were papillary carcinoma in 323 cases (51.8%), follicular carcinoma in 143 cases (22.9%) and anaplastic carcinoma in 102 cases (16.3%). The average age of patients at autopsy was 58 years for papillary carcinoma cases, 62.4 years for follicular carcinoma cases and 61.7 years for anaplastic carcinoma cases. The incidence of metastasis to lymph nodes and to organs was 47.3% and 51.5%, respectively in cases of follicular carcinoma and 73.3% and 98.0%, respectively in cases of anaplastic carcinoma. Autopsy revealed an otherwise unnoticed thyroid cancer in 457 cases, which accounted for 61.2% of the entire autopsy cases of malignancy of this organ. A so-called multiple cancer, i.e. the concurrence of carcinomas in the thyroid gland and other organs, was seen in 239 cases (32.3%).

10 0 0 0 OA 甲状腺と放射線

著者
山下 俊一 難波 裕幸 長瀧 重信
出版者
一般社団法人 日本内分泌学会
雑誌
日本内分泌学会雑誌 (ISSN:00290661)
巻号頁・発行日
vol.69, no.10, pp.1035-1043, 1993-11-20 (Released:2012-09-24)
参考文献数
50

The topic“Thyroid and Radiation”is both an old and a new area to be solved by human beings. The thyroid is an organ that is usually susceptible to exposure to ionizing radiation, both by virtue of its ability to concentrate radioiodine (internal radiation) and by routine medical examination: Chest X-ray, Dental X-ray, X-irradiation of cervical lymphnodes etc. (external radiation). Iodine-131 is widely used for the therapy of Graves' disease and thyroid cancers, of which the disadvantage is radiation-induced hypothyroidism but not complications of thyroid tumor. The thyroid gland is comparatively radioresistant, however, the data obtained from Hiroshima, Nagasaki and Marshall islands indicates a high incidence of external radiation-induced thyroid tumors as well as hypothyroidism. The different biological effects of internal and external radiation remains to be further clarified. Interestingly, recent reports demonstrate the increased number of thyroid cancer in children around Chernobyl in Belarus. In this review, we would like to introduce the effect of radiation on the thyroid gland at the molecular, cellular and tissue levels. Furthermore the clinical usefulness of iodine-131, including the safety-control for radiation exposure will be discussed.
著者
新美 仁男 佐々木 望 松本 生 首村 紀夫 中村 陽子
出版者
一般社団法人 日本内分泌学会
雑誌
日本内分泌学会雑誌 (ISSN:00290661)
巻号頁・発行日
vol.52, no.10, pp.1040-1045, 1976-10-20 (Released:2012-09-24)
参考文献数
14
被引用文献数
1

An epidemiological survey on the incidence of chronic lymphocytic thyroiditis in childhood was performed in 11,353 apparently healthy school children in Chiba prefecture, Japan.The present study included 9,416 school children (4,401 boys and 5,015 girls, ages 6-18 yrs) in Chiba City and 1,937 children (744 boys and 1,193 girls, ages 16-18 yrs) in Tateyama City. The first group was selected as a representative of urban area, and the second group was selected as that of seaside area.Children having goiter were selected for testing antithyroglobulin and antimicrosomal antibodies in sera. Final diagnosis of chronic lymphocytic thyroiditis was based on histological specimens obtained by needle biopsies on the antithyroid antibody positive subjects.The overall incidence of chronic lymphocytic thyroiditis in these children was 1.7 per 1,000 children. There was a considerable sex difference in the prevalence. None of the patients were boys. In girls the incidence increased with age : ages 6-12 0.9, ages 13-15 4.6 and ages 16-18 3.1-4.2 per 1,000, respectively. The incidence in the seaside area, 2.6 per 1,000 was not significantly higher than that in the urban area, 1.8 per 1,000. Histologically, all cases were classified as focal thyroiditis.
著者
河野 哲郎 松浦 講平 本田 律生 西村 弘 田中 信幸 岡村 均
出版者
一般社団法人 日本内分泌学会
雑誌
日本内分泌学会雑誌 (ISSN:00290661)
巻号頁・発行日
vol.68, no.11, pp.1188-1196, 1992-11-20 (Released:2012-09-24)
参考文献数
14

To investigate the usefulness of a semi-quantitative assay of urinary luteinizing hormone (LH) for predicting ovulation, the relationship among urinary LH, serum LH, serum estradiol (E2) and ultrasonographic observations of follicles were examined in 32 infertile women (35 cycles) at spontaneous (7), clomiphene (13) or cyclofenil (3) induced or hMG (12) induced cycles. Their urine samples were collected 3 times a day for LH assay, starting from about the 10th cycle day or when follicles having a diameter of 10mm or more were detected to the day of ultrasonographical confirmation of follicle ruptures. In the morning on these days, blood was taken twice daily for LH and E2 determination at intervals of 30 min. In spontaneous cycles, urinary LH was (P<0.001) correlated to a significant extent with the serum LH and E2 levels, and follicle rupture was observed 1.9 days after the urine LH surge. In contrast, there was no significant correlation between the urine LH and serum LH or E2 levels in the ovulation induced cycles. In addition, the period from urine LH positive to follicle rupture was significantly (P<0.05) prolonged in those cycles compared with that in spontaneous cycles. These results suggested that the urine LH determination was good for predicting ovulation in spontaneous cycles, but it was also necessary to monitor the follicle sizes by ultrasonography in ovulation induced cycles.
著者
石井 磨
出版者
一般社団法人 日本内分泌学会
雑誌
日本内分泌学会雑誌 (ISSN:00290661)
巻号頁・発行日
vol.18, no.6, pp.531-537,27, 1942-09-20 (Released:2012-09-24)
参考文献数
5

Unter den gesamten Untersuchungsindividuen von 1150 tritt die Pubertät bei Fleischessern, Pflanzenessern und Mischessern in Japan durchschnittlich fast gleichzeitig ein. Der Pubertätseintritt in Hokkaido, Sachalin (2 Fälle), Formosa und Okinawa (6 Fälle) war auch fast gleichzeitig. Die Pubertät der männlichen abnorm. Geschlechtlichen die nicht Interesse an den Frauen sondern an Männern nehmen, ist etwas später als die der normalen Männer. Aus dieser Tatsache kann ich entnehmen, bass, die Bildungsmenge des Hodenhormons dieser abnormen Veranlagten wahrscheinlich klein ist.
著者
川合 眞一
出版者
一般社団法人 日本内分泌学会
雑誌
日本内分泌学会雑誌 (ISSN:00290661)
巻号頁・発行日
vol.61, no.3, pp.145-161, 1985-03-20 (Released:2012-09-24)
参考文献数
47
被引用文献数
3 3

Although rifampicin (RFP) is known to be one of the potent hepatic microsomal enzyme inducers, little has been reported about the detailed pharmacokinetics of glucocorticoids in patients under RFP therapy. In this paper, the metabolism of cortisol, prednisolone and dexamethasone were investigated comparatively by simultaneous injection of these glucocorticoids.Eleven patients under RFP therapy, including 7 with tuberculosis together with collagen diseases and 4 with tuberculosis alone, were studied. Sixteen normal volunteers and 4 patients with collagen diseases not under RFP therapy were also examined as controls. After 1 mg of betamethasone was administered orally on the previous night for the suppression of endogenous cortisol, a mixed solution of 1mg each of cortisol, prednisolone and dexamethasone was given intravenously. Plasma steroid levels of periodically collected blood samples were determined by respective radioimmunoassay after extraction with dichloromethane and purification by paper chromatography.Half-times of plasma disappearance (t1/2), metabolic clearance rates (MCR) and total apparent distribution volumes (V) of these glucocorticoids were calculated using the single compartment model.The mean values of t1/2 of cortisol, prednisolone and dexamethasone in patients with collagen diseases under RFP therapy were 1.8±0.3 (Mean±SD) (p<0.05), 1.4±0.2 (p<0.001) and 1.3±0.3 hours (p<0.001), respectively, which were significantly shortened when compared with normal subjects (cortisol, 2.1±0.2; prednisolone, 2.5±0.7; dexamethasone, 3.5±1.0 hours). The MCR of cortisol, prednisolone and dexamethasone in these patients were 139±57,141±53 (p<0.01) and 722±137 l/day/m2 (p<0.001), respectively, which were increased when compared with normal subjects (cortisol, 114±20; prednisolone, 75±25; dexamethasone, 153±45 l/day/m2). The metabolism of these glucocorticoids in patients with collagen diseases under RFP therapy were also accelerated when compared with those in patients with collagen diseases not under RFP therapy.The t1/2 of cortisol, prednisolone and dexamethasone in patients with tuberculosis alone under RFP therapy were 1.3±0.3 (p<0.001), 1.4±0.5 (p<0.01) and 1.2±0.3 hours (p<0.001), respectively, which were significantly shortened when compared with normal subjects. The MCR of prednisolone and dexamethasone in these patients were significantly increased (136±72, p<0.05 and 868±226, p<0.001 l/day/m2) when compared with normal subjects.When these data were expressed as percent of mean values in normal subjects, the mean %-t1/2 of cortisol, prednisolone and dexamethasone were 86%, 56% and 37%, and the mean %-MCR were 122%, 188% and 472%, respectively, in patients with collagen diseases under RFP therapy. The mean %-t1/2 of these glucocorticoids in patients with tuberculosis alone under RFP therapy were 62%, 56% and 34%, and the mean %-MCR were 105%, 181% and 567%, respectively.The V of these glucocorticoids in patients under RFP therapy were almost the same as normal subjects except for that of dexamethasone, which was about twice as much as normal in patients both with or without collagen diseases.Five patients who were examined again after discontinuance of RFP showed normalization of this accelerated metabolism of prednisolone and dexamethasone.It may be concluded that marked differences in the degrees of accelerated metabolism between these glucocorticoids, the order of which was dexamethasone, prednisolone and cortisol, were observed in patients under RFP therapy. These results are very important in the concurrent use of glucocorticoid and RFP, especially when the tuberculosis therapy is needed in patients with collagen diseases under glucocorticoid therapy,
著者
若林 茂
出版者
一般社団法人 日本内分泌学会
雑誌
日本内分泌学会雑誌 (ISSN:00290661)
巻号頁・発行日
vol.68, no.6, pp.623-635, 1992-06-20 (Released:2012-09-24)
参考文献数
25
被引用文献数
3 3

It is widely acknowledged that high viscosity water-soluble dietary fibers such as pectin and guar gum affect a lowering of blood glucose levels and a reducing of insulin secretion following a sugar load. However, as dietary fibers vary in origin and in chemical properties, their physiological functions differ as well. In this study the effects of Indigestible Dextrin (PF-C), a low viscosity, water-soluble dietary fiber obtained through acid and heat-treatment of potato starch, on various aspects of sugar tolerance were examined.First, the influence of PF-C on sucrose hydrolysis was examined in rat intestinal mucosa cell homogenate confirming that PF-C did not inhibit sucrase activity. Then, in order to investigate the influence of PF-C on sugar digestion-absorption, an experiment was performed by using the everted intestinal sac of the rat in vitro. PF-C did not have an effect on glucose-transport into the serosal medium, whereas PF-C did inhibit the transport of hydrolyzed-glucose from sucrose, with no change in the hydrolysis of sucrose.Recently, Crane et al. reported that there is a specific route for hydrolyzed glucose from sucrose in glucose-absorption on the enteric surface (disaccharidase related transport system). The possibility exists that PF-C specifically affects this pathway. Further, total glucagon released into the serosal medium stimulated by both glucose and sucrose were reduced by PF-C.On the basis of these results, an oral sugar tolerance test was conducted in both rats and healthy human subjects. In male Sprague-Dawley rats (8 weeks old, 250-280g) concurrent administration of PF-C (0.6g/kg body weight) reduced an increase in plasma insulin levels with no change in glucose levels following a glucose (1.5g/kg body weight) load. Further noted were reductions in increases in both plasma glucose and insulin levels following a sucrose (1.5g/kg body weight) plus PF-C (0.6g/kg body weight) load to that of the sucrose (1.5g/kg body weight) single load. These findings reflect the above mentioned in vitro results. Moreover, in healthy male subjects the increase in both plasma insulin and glucagon-like immunoreactivity (Gut GLI) levels following a Trelan-G75 load were significantly reduced by concurrent administration of PF-C.From these observations it would appear that the effectiveness of reducing insulin secretion by PF-C results due to the decrease in sugar absorption by inhibiting the disaccharidase-related transport system. As glucagon-like peptide 1 (GLP-1), [an incretin in the enteroinsular axis] secreted with Gut GLI from intestinal L cells, is known to enhance insulin secretion following a sugar load, the resulting effectiveness by PF-C to reduce insulin secretion is thought to be attributed to the action on this enteroinsular axis mechanism.
著者
石突 吉持 広岡 良文 谷川 俊一
出版者
一般社団法人 日本内分泌学会
雑誌
日本内分泌学会雑誌 (ISSN:00290661)
巻号頁・発行日
vol.70, no.10, pp.1093-1100, 1994-12-20 (Released:2012-09-24)
参考文献数
20
被引用文献数
1 3

In order to evaluate whether or not iodine intake in Japanese is variable among different aged subjects and also whether this variation is concordant with the age distribution in patients with chronic thyroiditis, we tried to examine the urinary iodine excretion of euthyroid people in various decades of age.One hundred and twenty outpatients without thyroid disorders, aged 22 to 77 y. o., were selected at random and were divided into 6 groups according to age. Mean total urinary iodine excretion (UIT) and concentration (UIC) were 336.1μg/day and 31.4μg/dl/cr, respectively, and they were in good correlation (r=+0.82, p<0.001). A straight line on log normal probability was recognized between the ratio of cumulative frequency and values of UIT. UIT and UIC were significantly correlated with serum nonhormonal iodine, respectively (r=+0.21, p<0.01; r=+0.28, p<0.01). These indicators in the 3rd decade were lower than those in the 6th decade (p<0.01, p<0.05). UIT increased with age up to the 6th decade and then decreased gradually to the 8th decade. Therefore, UIT in all the subjects formed a bell-shaped distribution with a significant peak in the 6th decade (H=12.1, p<0.05). Rates of renal iodine clearance (UIC/SNI) in the 6th decade increased significantly more than those in the 4th decade (p<0.01), and the distribution of those rates in the 6 groups were similar to that of UIT. The mean frequency of UIT in less than 200 μg/day of the necessary amounts of iodine intake was 32.5%, but it was 63.6% in the 3rd decade, whereas it was 19% in the 6th decade. The difference between the 3rd and 6th decades was significant (p<0.01).It was indicated that differences in the amounts of iodine intake in Japanese euthyroid people were present and that the distribution was virtually matched to the age distribution of the patients with chronic thyroiditis. The data suggest that the increment of iodine intake in the middle-aged group could affect the pathophysiology of autoimmune thyroid disorders.
著者
石突 吉持 広岡 良文 村田 善晴 富樫 和美
出版者
一般社団法人 日本内分泌学会
雑誌
日本内分泌学会雑誌 (ISSN:00290661)
巻号頁・発行日
vol.67, no.5, pp.622-629, 1991-05-20 (Released:2012-09-24)
参考文献数
12
被引用文献数
1 1

To elucidate whether soybeans would suppress the thyroid function in healthy adults, we selected 37 subjects who had never had goiters or serum antithyroid antibodies. They were given 30g of soybeans everyday and were divided into 3 groups subject to age and duration of soybean administration.In group 1, 20 subjects were given soybeans for 1 month. Groups 2 and 3 were composed of 7 younger subjects (mean 29 y. o.) and 10 elder subjects (mean 61 y. o.) respectively, and the subjects belonging to these groups received soybeans for 3 months. The Wilcoxon-test and t-test were used in the statistical analyses. In all groups, the various parameters of serum thyroid hormones remained unchanged by taking soybeans, however TSH levels rose significantly although they stayed within normal ranges. The TSH response after TRH stimulation in group 3 revealed a more significant increase than that ingroup 2, although inorganic iodide levels were lowered during the administration of the soybeans. We have not obtained any significant correlation between serum inorganic iodide and TSH.Hypometabolic symptoms (malaise, constipation, sleepiness) and goiters appeared in half the subjects in groups 2 and 3 after taking soybeans for 3 months, but they disappeared 1 month after the cessation of soybean ingestion.These findings suggested that excessive soybean ingestion for a certain duration might suppress thyroid function and cause goiters in healthy people, especially elderly subjects.