著者
Ono Tomonori S. Galanopoulou Aristea L. Moshé Solomon
出版者
一般社団法人 日本てんかん学会
雑誌
Epilepsy & Seizure
巻号頁・発行日
vol.6, no.1, pp.19-29, 2013

Infantile spasms (IS) are an age-specific epileptic syndrome with overall poor outcome and are recognized as one of the 'catastrophic epilepsies'. Current conventional therapies including adrenocorticotropic hormone and vigabatrin often fail to control the spasms and improve the long-term outcome, especially in cases with structural/metabolic etiologies. To improve this situation, new treatments with a disease modifying potential must be identified. Recent translational studies have led to the development of several animal models of IS that reflect their multiple etiologies. Among these, the multiple hit model has been used to screen new promising therapies that, in the future, may be explored in clinical trials.

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こんな論文どうですか? Getting rid of the catastrophe: frontier research in infantile spasms(Ono Tomonoriほか),2013 … https://t.co/JSw4ENwgUz

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