著者

SUZUKI FUJIO SUZUKI CHIEKO SHIMOMURA EMIKO MAEDA HIROSHI FUJII TOSHIKATSU ISHIDA NAKAO

出版者

公益財団法人 日本感染症医薬品協会

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.32, no.12, pp.1336-1345, 1979

被引用文献数

28

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Oral (PO) administration of KS-2 to adult DDI mice resulted in a peak serum interferon (IF) titer of 800 units (U)/ml 20 hours after administration with detectable levels persisting until 30 hours. After intraperitoneal (IP) injection, a peak serum IF titer of 1, 600 U/ml was<br>detected and it followed the same time course as that of oral administration. The IF induced<br>by KS-2 shared certain physico-chemical properties with the standard preparation of immune IF and was not neutralized by an antiserum against type I IF. In mice infected intranasally (IN) with influenza A₂ (H₂N₂) virus, KS-2 was found to possess significant protective activities.<br>Efficacy of the agent was evidenced by an increase in survivor number, a prolongation of mean survival time, an inhibition of the development of lung consolidation induced by the viral infection and a decrease in virus titer in lung tissues. Both PO and IP administrations of KS-2 protected mice against infection and significant antiviral activities were achieved not only by prophylactic but also chemotherapeutic administration. No virocidal or virostatic activities of KS-2 to the influenza virus were found <i><i>in vitro</i></i>. The protective activities of KS-2 against influenza virus infection in mice are discussed in view of the immunopotentiation of the host animals.