著者

TORU KINO HIROSHI HATANAKA SUSUMU MIYATA NORIAKI INAMURA MICHIHISA NISHIYAMA TOSHIMI YAJIMA TOSHIO GOTO MASAKUNI OKUHARA MASANOBU KOHSAKA HATSUO AOKI TAKENORI OCHIAI

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.40, no.9, pp.1256-1265, 1987-09-25 (Released:2006-04-19)

参考文献数

16

被引用文献数

241 780

---

The immuno-pharmacological profile of a novel immunosuppressive agent, FK-506 produced by a streptomycete, is presented here. We proceeded to test the effect of the agent on various in vitro immune systems. It showed that mixed lymphocyte reaction, cytotoxic T cell generation, the production of T cell-derived soluble mediators such as interleukin 2 (IL-2), interleukin 3 and gamma-interferon and the expression of the IL-2 receptor were suppressed by this agent. The IC50 values of FK-506 and ciclosporin (CS) in all tests were approximately 0.1nM and 10nM, respectively. Therefore, the novel agent, FK-506 suppressed in vitro immune systems at about hundred times lower concentration than CS.

著者

KIMBERLY D. MCBRIEN RONALD L. BERRY SUSAN E. LOWE KIM M. NEDDERMANN ISIA BURSUKER STELLA HUANG STEVEN E. KLOHR JOHN E. LEET

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.48, no.12, pp.1446-1452, 1995-12-25 (Released:2006-04-19)

参考文献数

6

被引用文献数

22 76

---

The new cytotoxic agents rakicidins A and B were isolated from cultured broth of a Micromonospora sp. Spectroscopic and amino acid analysis has shown that rakicidin A is a new cyclic lipopeptide, consisting of 4-amino-penta-2, 4-dienoic acid, 3-hydroxy-2, 4, 16-trimethylheptadecanoic acid, sarcosine, and 3-hydroxyasparagine. Rakicidin B differs by one methylene group in the lipid side chain. These compounds exhibited cytotoxicity against the Ml09 cell line.

著者

CLAUDE VÉZINA ALICIA KUDELSKI S. N. SEHGAL

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.28, no.10, pp.721-726, 1975 (Released:2006-04-12)

参考文献数

6

被引用文献数

244 1139

---

A streptomycete was isolated from an Easter Island soil sample and found to inhibit Candida albicans, Microsporum gypseum and Trichophyton granulosum. The antibioticproducing microorganism was characterized and identified as Streptomyces hygroscopicus. The antifungal principle was extracted with organic solvent from the mycelium, isolated in crystalline form and named rapamycin. Rapamycin is mainly active against Candida albicans; minimum inhibitory concentration against ten strains ranged from 0.02 to 0.2 μg/ml. Its apparent activity against Microsporum gypseum and Trichophyton granulosum is lower because of its instability in culture media on prolonged incubation required by these fungi. No activity was observed against gram-positive and gram-negative bacteria. Acute toxicity in mice is low.

著者

MITSUAKI TSUNAKAWA OSAMU TENMYO KOJI TOMITA NOBUAKI NARUSE CHIKAKO KOTAKE TAKEO MIYAKI MASATAKA KONISHI TOSHIKAZU OKI

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.45, no.2, pp.180-188, 1992-02-25 (Released:2006-04-19)

参考文献数

14

被引用文献数

31 33

---

A strain of Amycolatopsis orientalis No. Q427-8 (ATCC 53884) was found to produce a complex of new antiviral antibiotics, quartromicin which consisted of at least six components A1, A2, A3, D1, D2 and D3. Structural studies suggested that they are a novel type of molecules unrelated to any known antibiotics. Each component of quartromicin exhibited antiviral activity against herpes simplex virus type 1, influenza virus type A and human immunodeficiency virus.

著者

MASARU YOSHIDA MASAMI EZAKI MICHIZANE HASHIMOTO MICHIO YAMASHITA NOBUHARU SHIGEMATSU MASAKUNI OKUHARA MASANOBU KOHSAKA KOKI HORIKOSHI

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.43, no.7, pp.748-754, 1990-07-25 (Released:2006-04-19)

参考文献数

12

被引用文献数

85 99

---

Streptoverticillium fervens produced a new antibiotic, FR-900848, which has a high specific activity against filamentous fungi. Purified by solvent extraction and column chromatography, the compound appears as colorless crystals. Its structure is C32H43N3O6, which consists of 5'-amino-5'-deoxy-5, 6-dihydrouridine with an unsaturated fatty acid having unprecedented four serial and one isolated cyclopropane rings.

著者

AKIRA ENDO MASAO KURODA YOSHIO TSUJITA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.29, no.12, pp.1346-1348, 1976 (Released:2006-04-12)

参考文献数

9

被引用文献数

375 726

著者

THEODOR FEHR JÖRG KALLEN LUKAS OBERER JEAN-JACQUES SANGLIER WOLFGANG SCHILLING

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.52, no.5, pp.474-479, 1999-05-25 (Released:2008-09-19)

参考文献数

4

被引用文献数

70 87

---

A novel class of macrolides, the sanglifehrins, was discovered by screening of actinomycete strains with a cyclophilin-binding assay. The chemical structures and absolute stereochemistries of the sanglifehrins A, B, C and D were determined unambiguously by NMR-techniques and by X-ray crystallography of the complex with cyclophilin A. Sanglifehrin A consists of a 22-membered macrocycle containing a tripeptide subunit and features in position 23 a chain of nine carbon atoms bearing a spirocyclic substituent. Sanglifehrins A and B are genuine metabolites whereas sanglifehrins C and D are artefacts.

著者

T. ANKE F. OBERWINKLER W. STEGLICH G. SCHRAMM

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.30, no.10, pp.806-810, 1977 (Released:2006-04-12)

参考文献数

2

被引用文献数

124 211

---

The strobilurins are two antifungal antibiotics which were isolated from the mycelium of Strobilurus tenacellus strain No. 21602. The strobilurins A and B are highly active against yeasts and filamentous fungi. In vitro antitumor activity was tested using cells of the asciticform of EHRLICH carcinoma. The strobilurins strongly inhibited the incorporation of radioactive leucine, uridine, and thymidine into the acid-insoluble fraction of cells (protein, RNA, and DNA). The molecular formulas as determined by high resolution mass spectrometry are C16H18O3 for strobilurin A and C17H19ClO4 for strobilurin B.

著者

KUNIO ANDO SEIKICHI SUZUKI TETSUJI SAEKI GAKUZO TAMURA KEI ARIMA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.22, no.5, pp.189-194, 1969-05-25 (Released:2006-04-12)

参考文献数

11

被引用文献数

31 36

---

A new antibiotic, funiculosin, C27H41NO7, was isolated from the filter cake of the fermented broth of Penicillium funiculosum THOM. Funiculosin is a neutral lipophilic substance which inhibits both DNA and RNA viruses as tested in infected primary chick embryo fibroblast cell monolayer and also some pathogenic fungi such as Tricophyton mentagrophytes and Candida albicans.

著者

K. ECKARDT H. THRUM G. BRADLER E. TONEW M. TONEW

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.28, no.4, pp.274-279, 1975 (Released:2006-04-12)

参考文献数

5

被引用文献数

25 33

---

Streptovirudin is a complex of antibiotics isolated from fermentation of a Streptomyces strain. Eight components have been isolated as pure substances, designated as streptovirudins A1, A2, B1, B2, C1, C2, D1 and D2. The streptovirudins are chemically and biologically related to each other and appear to be a new family of antibiotics exhibiting activity against a variety of Gram-positive bacteria, mycobacteria, and various DNA- and RNA-viruses. According to their physico-chemical properties these antibiotics have been classified in series I and II. The streptovirudins of series II (A2, B2, C2, D2) are related to the reported antibiotics tunicamycin, mycospocidin and 24010.

著者

AKIKO KATO TETSUJI SAEKI SEIKICHI SUZUKI KUNIO ANDO GAKUZO TAMURA KEI ARIMA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.22, no.7, pp.322-326, 1969-07-25 (Released:2006-04-12)

参考文献数

4

被引用文献数

16 19

---

A new antibiotic, oryzachlorin, C26H31O8N2S2Cl(λmax 298mμ in ethanol) has been isolated from Aspergillus oryzae. It strongly inhibits the growth of many yeasts but has no effect on bacteria or filamentous fungi. It also has antiviral activity in vitro.

著者

AKIRA NAKAGAWA HIROSHI TOMODA MAI VAN HAO KEIKO OKANO YUZURU IWAI SATOSHI OMURA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.38, no.8, pp.1114-1115, 1985 (Released:2006-04-19)

参考文献数

6

被引用文献数

22 22

著者

GAKUZO TAMURA KUNIO ANDO SEIKICHI SUZUKI AKIRA TAKATSUKI KEI ARIMA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.21, no.2, pp.160-161, 1968-02-25 (Released:2006-04-12)

参考文献数

5

被引用文献数

92 95

著者

HIROSHI SANO TOSHIAKI SUNAZUKA HARUO TANAKA KINYA YAMASHITA RYO OKACHI SATOSHI OMURA

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.38, no.10, pp.1350-1358, 1985 (Released:2006-04-19)

参考文献数

5

被引用文献数

6 10

---

3, 3"-Di-O-acyl-4"-O-sulfonyl and 3, 3"-di-O-acyl-4"-O-alkyl derivatives of spiramycin I were synthesized and evaluated by four parameters, antibacterial activity, affinity to ribosomes, lypophilicity and therapeutic effects. Among them, 3, 3"-di-O-acetyl-4"-O-mesyl and 3, 3"-di-O-acetyl-4"-O-methylspiramycin I having relatively small substituents at 4"-position were the most effective in mouse protection tests, and the results were comparable to acetylspiramycin.

著者

MASAAKI SAKURAI JUN KOHNO MAKI NISHIO KOZO YAMAMOTO TORU OKUDA KIMIO KAWANO NORIYUKI NAKANISHI

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.54, no.8, pp.628-634, 2001-08-25 (Released:2008-09-19)

参考文献数

12

被引用文献数

10 9

---

A new transcriptional up-regulator designated TMC-205 was discovered from the fermentation broth of an unidentified fungal strain TC 1630 by using an SV40 promoterluciferase reporter assay. Based on spectroscopic analyses, its structure was determined to be (E)-6-(3-methyl-1, 3-butadienyl)-1H-indole-3-carboxylic acid. Expression of the luciferase activity was activated ca. 2-, 4-, and 6-fold by 1, 10, and 100μM TMC-205, respectively. TMC-205 activated the transcriptional activity in a manner dependent on the presence of the enhancer element of SV40 in its promoter region.

著者

KOKO SUGAWARA MASAMI HATORI YUJI NISHIYAMA KOJI TOMITA HIDEO KAMEI MASATAKA KONISHI TOSHIKAZU OKI

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.43, no.1, pp.8-18, 1990-01-25 (Released:2006-04-19)

参考文献数

3

被引用文献数

54 65

---

Streptomyces hygroscopicus No. P247-71 (ATCC 53709) produced a novel antibiotic eponemycin which exhibited specific in vivo antitumor effect against B16 melanoma. Structural studies assigned (4S)-1, 2-epoxy-2-hydroxymethyl-4-(N-isooctanoyl-L-serylamino)-6-methylhept-6-ene-3-one to eponemycin which is unrelated to the known antitumor antibiotics.

著者

WILLIAM L. PARKER WILLIAM H. KOSTER CHRISTOPHER M. CIMARUSTI DAVID M. FLOYD WEN-CHIH LIU MARLENE. RATHNUM

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.35, no.2, pp.189-195, 1982 (Released:2006-04-12)

参考文献数

16

被引用文献数

23 16

---

A novel monocyclic β-lactam antibiotic SQ 26, 180 has been isolated from bacteria and the structure, (R)-3-acetylamino-3-methoxy-2-oxo-1-azetidinesulfonic acid was deduced from its spectroscopic properties. Structural confirmation and assignment of absolute configuration were made by synthesis from 6-aminopenicillanic acid.

著者

GEORGE G. YARBROUGH DEAN P. TAYLOR ROBERT T. ROWLANDS MARK S. CRAWFORD LINDA L. LASURE

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.46, no.4, pp.535-544, 1993-04-25 (Released:2006-04-19)

参考文献数

16

被引用文献数

38 59

著者

MINORU SANADA TETSUJI MIYANO SHUICHI IWADARE

出版者

JAPAN ANTIBIOTICS RESEARCH ASSOCIATION

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.39, no.2, pp.304-305, 1986 (Released:2006-04-19)

参考文献数

3

被引用文献数

6 11

著者

SUZUKI FUJIO SUZUKI CHIEKO SHIMOMURA EMIKO MAEDA HIROSHI FUJII TOSHIKATSU ISHIDA NAKAO

出版者

公益財団法人 日本感染症医薬品協会

雑誌

The Journal of Antibiotics (ISSN:00218820)

巻号頁・発行日

vol.32, no.12, pp.1336-1345, 1979

被引用文献数

28

---

Oral (PO) administration of KS-2 to adult DDI mice resulted in a peak serum interferon (IF) titer of 800 units (U)/ml 20 hours after administration with detectable levels persisting until 30 hours. After intraperitoneal (IP) injection, a peak serum IF titer of 1, 600 U/ml was<br>detected and it followed the same time course as that of oral administration. The IF induced<br>by KS-2 shared certain physico-chemical properties with the standard preparation of immune IF and was not neutralized by an antiserum against type I IF. In mice infected intranasally (IN) with influenza A₂ (H₂N₂) virus, KS-2 was found to possess significant protective activities.<br>Efficacy of the agent was evidenced by an increase in survivor number, a prolongation of mean survival time, an inhibition of the development of lung consolidation induced by the viral infection and a decrease in virus titer in lung tissues. Both PO and IP administrations of KS-2 protected mice against infection and significant antiviral activities were achieved not only by prophylactic but also chemotherapeutic administration. No virocidal or virostatic activities of KS-2 to the influenza virus were found <i><i>in vitro</i></i>. The protective activities of KS-2 against influenza virus infection in mice are discussed in view of the immunopotentiation of the host animals.