著者

福田 篤郎 秋山 節子

出版者

一般社団法人 日本生理学会

雑誌

The Japanese Journal of Physiology (ISSN:0021521X)

巻号頁・発行日

vol.13, no.5, pp.486-491, 1963

被引用文献数

3

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The resistance against endotoxin intoxication in endotoxin-tolerant rabbits was found to outlast far the ordinary “tolerance” in relation to the “macromolecular hematic syndrome” in which the clearing of endotoxin by the reticuloendothelial system might play a dominant role. The most characteristic in the tolerant state in relation to the resistance against the lethal effect of endotoxin was the lessening of the liver glycogen depletion after massive dose of endotoxin. That this might be due to the stability of liver metabolism was also suggested by the reduced metabolic response to thyroid in the tolerant state. The creatinuria induced by non-toxic dose of thyroid was found to be inhibited in the tolerant state.