著者
張 達聰
出版者
Japanese Society of Nephrology
雑誌
日本腎臓学会誌 (ISSN:03852385)
巻号頁・発行日
vol.11, no.6, pp.731-754, 1969

The administrations of glucocorticoid in normal rabbits for 6 weeks produced exudative lesions in the renal glomeruli. In the animals, in which the injection of heparin was started after, just at the time of, or even before the glucocorticoid treatment, a higher frequency of the occurence of those lesions was observed. In the animals, which were given warfarin simultaneously with corticosteroid, the occurence of those lesions were markedly inhibited. In the rabbits treated with heparin or warfarin alone, no such lesions were found. The concentration of NEFA in plasma rose up to abnormal high level. It was markedly higher in the animals treated with both glucocorticoid and heparin than in those treated with glucocorticoid alone. No increase of NEFA was noted in the rabbits treated with both glucocorticoid and warfarin. It is assumed from these results that the steroid nephropathy in the rabbit may be caused by an in-creased mobilization of NEFA, followed by the acceleration of blood coagulation process as secondary phenomen. The renal lesions seen 4 weeks after the injection of glucocorticoid has gradually regressed, if the injection was discontinued at that time.

言及状況

外部データベース (DOI)

Twitter (2 users, 2 posts, 0 favorites)

こんな論文どうですか? ステロイド腎症の実験的研究(第3報):抗血液凝固剤,ヘパリン(Heparin)ならびにワーファリン(Warfarin)の効果について(張 達聰),1969 https://t.co/8XEwOtbi6r

収集済み URL リスト