- 著者
- 張 達聰
- 出版者
- Japanese Society of Nephrology
- 雑誌
- 日本腎臓学会誌 (ISSN:03852385)
- 巻号頁・発行日
- vol.11, no.6, pp.731-754, 1969
The administrations of glucocorticoid in normal rabbits for 6 weeks produced exudative lesions in the renal glomeruli. In the animals, in which the injection of heparin was started after, just at the time of, or even before the glucocorticoid treatment, a higher frequency of the occurence of those lesions was observed. In the animals, which were given warfarin simultaneously with corticosteroid, the occurence of those lesions were markedly inhibited. In the rabbits treated with heparin or warfarin alone, no such lesions were found. The concentration of NEFA in plasma rose up to abnormal high level. It was markedly higher in the animals treated with both glucocorticoid and heparin than in those treated with glucocorticoid alone. No increase of NEFA was noted in the rabbits treated with both glucocorticoid and warfarin. It is assumed from these results that the steroid nephropathy in the rabbit may be caused by an in-creased mobilization of NEFA, followed by the acceleration of blood coagulation process as secondary phenomen. The renal lesions seen 4 weeks after the injection of glucocorticoid has gradually regressed, if the injection was discontinued at that time.
- 著者
- 山縣 邦弘 小山 哲夫 小林 正貴 成田 光陽
- 出版者
- Japanese Society of Nephrology
- 雑誌
- 日本腎臓学会誌 (ISSN:03852385)
- 巻号頁・発行日
- vol.32, no.10, pp.1045-1052, 1990
This study was undertaken to analyze the mechanisms of immune complex formation in Heymann nephritis. We isolated two different RTE antigens by gel filtration and prepared rabbit antisera against these antigens. By the indirect immunoflurescence method using normal rat renal tissues, the 65, 000 molecular weight antigen (=β) was observed not only in RTE, but also in the glomerular epithelium, epithelium of the small intestine, liver and spleen. On the other hand, the 35, 000 molecular weight antigen (=γ) existed in RTE and epithelium of the small intestine. When rats were injected intravenously with rabbit antiserum against β, glomerular depositions were observed within two hours. In rats injected with rabbit antiserum against r, no glomerular deposition was seen with-in 2 days, but fine granular depositions were observed after 6 days. When rat kidneys were perfused with rabbit antiserum against γ in saline by a single pass method, no glomerular deposition was seen. However, in rat kidneys perfused with preformed soluble γ-anti γ IC, fine granular depositions along the capillary walls were seen soon after the perfusion. Further the antigen which was reacted with anti γ antiserum was isolated from normal rat serum by immuno-affinity chromatography. These facts suggest that the mechanisms of IC formation may be due to not only in situ immune complex formation but also circulating immune complex deposition in Heymann nephritis.
- 著者
- SUMIKO HOMMA NAOKI MURAYAMA TATSUHIKO KODAMA NOBUHIRO YAMADA KEIICHI TAKAHASHI YASUSHI ASANO SAICHI HOSODA TOSHIO MURASE YASUO AKANUMA
- 出版者
- Japanese Society of Nephrology
- 雑誌
- 日本腎臓学会誌 (ISSN:03852385)
- 巻号頁・発行日
- vol.35, no.8, pp.999-1006, 1993-08-25 (Released:2010-07-05)
- 参考文献数
- 30
To study the metabolic abnormalities in familial lecithin-cholesterol acyltransferase (LCAT) deficiency, the effects of a long-term, low-fat diet and LCAT replacement therapy on plasma lipids and apolipoproteins were investigated in a patient with LCAT deficiency. The patient had elevated triglycerides (TG, 543.7 mg/dl) and phospholipids (PL, 350.3 mg/dl) and normal total cholesterol (TC, 206.9 mg/dl). Change to a low-fat diet reduced TC and TG by 20% and 75%, respectively. These reductions occurred mainly in the d<1.006 fraction. At baseline, the patient had normal apolipoprotein B (apo B), low apolipoprotein A-I (apoA-I) and apolipoprotein A-II (apoAII) and elevated apolipoprotein E (apo E). Long-term treatment with a low-fat diet increased plasma apoA-I and decreased apo E. However, urinary protein excretion did not change throughout the observed period. LCAT replacement with fresh frozen plasma (FFP) after the low-fat diet further reduced plasma apo E to the normal range. These results indicate that the elevated plasma apo E in LCAT deficiency was related not only to the lack of LCAT in the plasma, but also to fat intake. A low-fat diet may be effective in correcting lipid abnormalities. Moreover, plasma apo E may be a good indicator of the efficacy of diet therapy.
1 0 0 0 OA Renal Failure in Sisters with Cystinuria and the Management of Amino Acids in Chronic Hemodialysis
- 著者
- SHINICHI HOSOKAWA TADAO TOMOYOSHI JUICHI KAWAMURA OSAMU YOSHIDA
- 出版者
- Japanese Society of Nephrology
- 雑誌
- 日本腎臓学会誌 (ISSN:03852385)
- 巻号頁・発行日
- vol.27, no.3, pp.319-325, 1985 (Released:2010-07-05)
- 参考文献数
- 16
Two sisters received long-term hemodialysis to manage chronic renal failure resulting from treatment of their cystinuria. Both had progressive renal failure caused by D-penicillamine treatment after surgery for urolithiasis. These are the first reported cases involving sisters. The 34-year-old sister had received dialysis since April 1975 and her 26-year-old sister had been on dialysis since October 1977. There has been little variation in the treatment of chronic renal failure whether caused by cystinuria or by other diseases. However, we treated these sisters with cystinuria, along with other patients, by differential diet management. The balance of plasma amino acids improved remarkably after 3.5 years of treatment and both sisters are now undergoing excellent dialysis. The diet restricts methionine and crystine to 2.5 g/day.
- 著者
- Yoshihiro AKASHI Nobuyuki YOSHIZAWA
- 出版者
- Japanese Society of Nephrology
- 雑誌
- 日本腎臓学会誌 (ISSN:03852385)
- 巻号頁・発行日
- vol.37, no.8, pp.462-467, 1995 (Released:2010-07-05)
- 参考文献数
- 22
To evaluate the role of histones and ubiquitin in lupus nephritis, we searched for glomerular deposits of histones and ubiquitin in renal biopsy specimens from 53 patients with systemic lupus erythematosus (SLE) and 30 with non-lupus glomerulonephritis. Glomerular immunofluorescence staining revealed positive for histone H2A, H1 + H3, H4 and ubiquitin in 49.1% (26/53), 45.3% (24/53), 32.1% (17/53) and 22.6% (12/53) of the SLE patients, respectively. Non-SLE renal biopsies revealed absence of positive staining with histone H2A, H1 + H3, H4 and ubiquitin. The positive incidence of histone H1 + H3 and ubiquitin in diffuse proliferative lupus nephritis was significantly different (p<0.01) from that in minor glomerular abnormality. Levels of CH50 in patients with glomerular deposition of histone H1+H3 (p < 0.001) and ubiquitin (p < 0.01) were significantly lower than in patients without deposition. Levels of anti-DNA antibody in patients with glomerular deposition of histone H1 + H3 were significantly higher than in patients without deposition (p < 0.05). Only the positive incidence of glomerular deposition of ubiquitin was correlated with the histological activity index (p <0.05). These results suggest that histones and ubiquitin may play an important role in the induction of lupus nephritis.
1 0 0 0 尿中血小板(予報)
- 著者
- 河野 南雄 佐々木 則子 溝上 隆
- 出版者
- Japanese Society of Nephrology
- 雑誌
- 日本腎臓学会誌 (ISSN:03852385)
- 巻号頁・発行日
- vol.17, no.3, pp.171-189, 1975
Small bodies with suspicion of a platelet by its size and appearance with granules contained were found in the human urine. In this study, a comparison has been made between the small body and normal platelets in the blood and also between platelets suspended in normal urine supernatant by the Giemsa staining method, the phase microscopy and the scanning electron microscopy. By Giemsa staining and the phase microscopy, the small bodies and platelets suspended in urine supernatant were showed similar to that in blood. Through scanning electron microscope, the majority of platelets suspended in urine were spherical form with smooth surface, or dendritic form with pitted and irregular surface similar to that in blood, but some remained as discs which were swelling than that in blood. Moreover the surface of these various platelets in urine were like that of platelets in blood. The small bodies in urine were similar to platelets suspended in urine. Although further investigations are required, we would like to consider that these small bodies are platelets and platelets could be found in urine.
- 著者
- 大塚 雄司 原澤 信介 杉浦 仁 小池 美由紀 秋元 秀郎 石井 利明 阿部田 ひろみ 岡部 龍也 久代 登志男 上松瀬 勝男
- 出版者
- Japanese Society of Nephrology
- 雑誌
- 日本腎臓学会誌 (ISSN:03852385)
- 巻号頁・発行日
- vol.42, no.8, pp.619-624, 2000
Previous studies have shown that hypertension causes endothelial dysfunction. To study the influence of exogenous nitric oxide (NO) on endothelial dysfunction produced by hypertension, we administered a non-depressor dose of nipradilol to two-kidney, one clip renovascular hypertensive rats (2K1C). Sprague-Dawley rats underwent either sham surgery (G-l) or clipping of the left renal artery. From day seven, 2K1C were randomized into 3 groups, placebo treatment (G-2), nipradilol treament (G-3, ) and propranolol treatment (G-4). Urinary NO<SUP>-</SUP><SUB>2</SUB> +N0<SUP>-</SUP><SUB>3</SUB> (NOx) excretion (UNOxV) was measured 4 weeks after clipping, and then, acetylcholine (Ach), A23187, or sodium nitroprusside (SNP) -induced relaxation were measured in the aorta. Blood pressure was increased in G-2, G-3, and G-4 compared to G-1. UNOxV was lower in G-2, G-3, and G-4 compared to G-1, but UNOxV was higher in G-3 compared to G-2 and G-4. Although Ach or A23187-induced relaxation was significantly decreased in isolated artery from G-2, G-3, and G-4 compared with those from G-1. Ach- or A23187-induced relaxation was improved in G-3. SNP induced relaxation did not differ among the 4 groups. These results suggest that exogenous NO from nipradilol reduces the endothelial dysfunction caused by hypertension without changing the blood pressure.