著者

西岡 裕 西川 眞弓 土橋 均

出版者

日本法科学技術学会

雑誌

日本法科学技術学会誌 (ISSN:18801323)

巻号頁・発行日

vol.11, no.1, pp.53-75, 2006

被引用文献数

1

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A fully automated identification system for 35 benzodiazepines and their 29 metabolites was developed by gas chromatography-mass spectrometry (GC-MS) with a DB-5MS fused silica capillary column after trimethylsilyl (TMS) and trifluoroacetyl (TFA) derivatization, followed by registering both their retention times and mass spectra as the standard library data.<br>All the analytes except for rilmazafone and haloxazolam were detectable with and/or without TMS derivatization. TFA derivatization was found to be more effective in the more sensitive analysis of oxazolo-benzodiazepines except for flutazolam. Also, correction of their retention times by alkanes enabled to accurately identify on the different GC-MS systems with different lots of columns.<br>The present system allowed us to identify benzodiazepines and their metabolites in urine and blood more readily in a much shorter time, and it will be a powerful system for the analysis of benzodiazepines in the forensic chemistry and toxicology fields.