著者

中下 靜夫

出版者

一般社団法人 日本内分泌学会

雑誌

日本内分泌学会雑誌 (ISSN:00290661)

巻号頁・発行日

vol.26, no.10, pp.275-289, 1951-01-20 (Released:2012-09-24)

参考文献数

66

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According to the former opinions it has been thought that the atrophy of the accessory sexual organs and the hypoplasia of the secondary character are directly caused by the lack of testicular hormone.Prof. Tokumitsu has emphasized from his many experiments that deficiency syndromes of an endocrine gland are not merely negative phenomena resulting from the lack of this hormone, but positive phenomena resulfing from functional changes of other endocrine glands.The writer has injected the serum of the rabbit every day for over 3 weeks after castration, into mice (0.1cc. per 10g. bodyweight) and cocks (2cc. per kg. bodyweight) and studied the development of the sexual glands and the cockscomb. Consequently he has found an active substance in the serum from the castrated rabbit's ear vein which controls the development of the testis and the accessory sexual organs of the mice, and controls the development of their secondary character and cockscomb. The injected castrated cock brings on a stronger atrophy of the cockscomb than the non-injected one. And furthermore it invites the atrophy of the cockscomb without the sexual organ of the injected cock. The active substance is found in the blood of the thyroidectomized, adrenalectomized, thymisectomized or hypophysectomized rabbit after castration. However, it does not appear in the blood of the pinealectomized rabbit after castration and moreover the increase of the dark cells and the hypertrophy of the clear cells are shown in the pineal gland. Therefore the writer believes that the active substance is due to the hyper-product of the pineal gland hormone resulting from the hyperfunction of the same gland. The active substance is insoluble in ether, but soluble in alcohol.