著者

前田 頼伸 小西 敏夫 西園寺 真二 船越 幸代 中村 護 仁井 雅子 正木 史子 突合 皐月

出版者

日本医療薬学会

雑誌

病院薬学 (ISSN:03899098)

巻号頁・発行日

vol.25, no.5, pp.517-524, 1999-10-10

参考文献数

12

被引用文献数

11

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To elucidate the current status of the dosage regimen of vancomycin, we reviewed its therapeutic drug monitoring (TDM) data obtained from 99 patients undergoing vancomycin treatment at the Chugoku Rousai Hospital. The plasma concentrations of vancomycin at one dosage under 750 mg deviated from its therapeutic ranges (the level at one hour after the end of infusion : 25-40 μg/mL, trough level :≦10μg/mL). Therefore, the dosing interval at a uniform dosage of 1000 mg was calculated from a vancomycin nomogram reported by Moellering et al., and the utility of the dosing interval at the uniform dosage of 1000 mg combined with a creatinine clearance nomogram reported by Nielsen et al. was examined. As a result, the plasma levels of 66 percent of the subjects were controlled within the accepted therapeutic ranges in the early stage. Accordingly, the nomogram of vancomycin prepared as an indication in the early stage in our hospital was thus concluded to be clinically acceptable.

著者

中村 護光

出版者

長野工業高等専門学校

雑誌

長野工業高等専門学校紀要 (ISSN:02861909)

巻号頁・発行日

vol.38, pp.95-102, 2004-06-30

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In the latter half of the 1990s, an emerging business opportunity in the American education industry attracted the interest of venture businesses. They now forge management contracts with public schools and school districts, providing them with learning programs, and thus helping them reconstruct themselves and revitalize their educational services. Since the 1983 publication of A Nation at Risk by the National Commission on Excellence in Education, many American parents and taxpayers have been dissatisfied with the prevailing state of public education. ln the meantime, state educational reforms have allowed school districts to loosen their control over schools. Such decentralization policies have allowed site-based management, and seen the birth of charter schools. Now accountability systems complying with the federal No Child Left Behind (NCLB) regulations have been implemented in many states. Reconstitution and takeover of schools by local authorities have become reality. Seizing this opportunity, private education management organizations have embarked on the business of managing imperiled schools. Thus, contract schools were born. The traditional American public education system is now being challenged by privatization. The meaning of public education and even the value of its existence have been called into question. This paper reviews this trend toward privatization and possible future developments.