著者

稲葉 一郎 大浦 華代子 中田 雄一郎 今井 輝子

出版者

一般社団法人 日本医薬品情報学会

雑誌

医薬品情報学 (ISSN:13451464)

巻号頁・発行日

vol.21, no.1, pp.1-8, 2019-05-31 (Released:2019-06-21)

参考文献数

11

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Objective: The use of generic products is a solution to the increasing healthcare cost in Japan. The pharmaceutical companies are trying to develop several generic products suitable to patient’s taste. The contribution of pharmacist by selecting generic product to each patient and a collection of patient’s opinion for products may accelerate the development of generic products improved usability for patients and medical workers. The present study examined the storage of generic products of sennoside in pharmacies and the patient preference for selection of generic products in 2003 and 2016 in Kumamoto, Japan.Methods: Sennoside was selected as a model drug, since it developed several generic products for long period. The survey on storage of sennoside pharmaceutics and the questionnaire survey for its generic products to patients were conducted at ethical pharmacies. The appearance and the dissolution of sennoside from generic tablets were compared with original product, Pursennid.Results: Thirteen sennoside products were stored in 2003 and 2016. The number of pharmacies that stored generic products increased from 33 to 54% in 13 years. The largest number of patients preferred Pursennid in 2003. In contrast, two generic products were more preferred than Pursennid in 2016. Interestingly, the reasons for preferring products were almost the same between 2003 and 2016, and their majority was color and size of tablet. The generic products tend to have a thinner thickness and larger diameter than Pursennid. The most preferred generic product in 2016 showed a faster dissolution of sennoside than Pursennid. However, the use of generic products is mainly related to their tablet appearances due to unrelation between the pharmacological effect of sennoside and its dissolution in GI tract.Conclusion: In the development of generic products of sennoside, as well as quality, the appearance is an important factor.

著者

中田 雄一郎

雑誌

大阪大谷大学紀要 = Bulletin of Osaka Ohtani University (ISSN:18821235)

巻号頁・発行日

vol.54, pp.41-55, 2020-02-20

著者

小畑 友紀雄 出口 粧央里 山口 瑞季 稲葉 一訓 長井 紀章 中田 雄一郎

雑誌

日本薬学会第142年会(名古屋)

巻号頁・発行日

2022-02-01

著者

中田 雄一郎

出版者

公益社団法人 日本薬剤学会

雑誌

薬剤学 (ISSN:03727629)

巻号頁・発行日

vol.75, no.1, pp.65-71, 2015 (Released:2015-01-01)

参考文献数

10

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From descriptions on the package inserts and interview forms accessible on the home page of the Pharmaceuticals and Medical Devices Agency (PMDA), the characteristics of active pharmaceutical ingredients, pharmaceutical production, and formulations of 106 glaucoma therapeutic agents currently used in clinical practice in Japan were analyzed. Since eye drops are a sterile preparation and are administered multiple times, their efficacy, safety, stability and preservation must be taken into consideration. The pH (4-8) and osmotic pressure (0.6-1.6) were well controlled within a fixed range and some additives were compounded in the eye drops for the purpose of making the users feel more comfortable. It was also found that there was a difference in the use of solubilizing agents and preservatives between domestic and global pharmaceutical companies. There has been no article to compare the eye drop formulations of glaucoma therapeutic agents for 45 years; therefore, this paper will help to show future directionality of the preparation development of eye drops.

著者

中田 雄一郎

出版者

大阪大谷大学志学会

雑誌

大阪大谷大学紀要 = Bulletin of Osaka Ohtani University (ISSN:18821235)

巻号頁・発行日

vol.51, pp.1-14, 2017