1 0 0 0 OA Studies on as-Triazine Derivatives. XVI. Reaction of 1, 2, 4-Triazinecarbonitriles with Carbanions
- 著者
- 大場 節哉 今野 昌悦 山中 宏
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.39, no.2, pp.486-488, 1991-02-25 (Released:2008-03-31)
- 参考文献数
- 25
- 被引用文献数
- 19 33
A cyano group in 1, 2, 4-triaznes, regardless of its position, acted as an effective leaving group in reactions with carbanions. Thus, the reactions gave the corresponding substituted products in place of the compounds formed by addition reaction of carbanions to the cyano group. Grignard reaction of these carbonitriles is also described.
1 0 0 0 ピリミジン誘導体の研究-3-シアノピリミジン類のグリニャ-ル反応
- 著者
- 山中 宏 江戸 清人 今野 昌悦
- 出版者
- 公益社団法人日本薬学会
- 雑誌
- 薬学雑誌 (ISSN:00316903)
- 巻号頁・発行日
- vol.97, no.7, pp.p726-730, 1977-07
Reaction of 2-cyano-4-methoxy-6-methyl- (I), 4-cyano-6-methoxy-2-methyl- (II), 5-cyano-4-methoxy-2-methyl- (III), and 5-cyano-4,6-dimethoxy-2-methylpyrimidine (IV) with Grignard reagents is described. While 2-cyano and 4-cyano derivatives (I, II) were transformed to the corresponding pyrimidinyl ketones as expected, 5-cyano derivatives (III, IV) were converted to the addition products, 5-cyano-6-ethyl-1,6-dihydro-4-methoxy-2-methyl- (VIIa) and 5-cyano-2-ethyl-1,2-dihydro-4,6-dimethoxy-2-methylpyrimidine (XI), respectively.