著者

佐々木 武仁

出版者

特定非営利活動法人 日本歯科放射線学会

雑誌

歯科放射線 (ISSN:03899705)

巻号頁・発行日

vol.37, no.1, pp.3-14, 1997-06-05 (Released:2011-09-05)

参考文献数

40

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Radiation carcinogenesis has been thought as a stochastic phenomenon without any threshold dose of radiation. Although this concept is very important, the presence or absence of a threshold dose in the dose-response relationship is difficult to directly confirm. This review discusses the implication of recent analysis of cancer mortality among atomic bomb survivors and multistep genomic changes involved in human carcinogenesis in relation to the radiation carcinogenesis at low doses. The remarkable similarity in the both shape and magnitude of the dose responses curve is seen between mutational cellular events and cancer incidence among atomic bomb survivors. In view of the increasing evidence for radiobiological mechanisms of radiation carcinogenesis including activation of oncogenes and inactivation of tumor suppressor genes and for analysis in the models of dose-response relationship, it seems likely that radiation is responsible for one mutational event in multistep genomic changes in carcinogenesis.

著者

佐々木 武仁

出版者

特定非営利活動法人 日本歯科放射線学会

雑誌

歯科放射線 (ISSN:03899705)

巻号頁・発行日

vol.46, no.3, pp.126-129, 2006-09-30 (Released:2007-08-17)

参考文献数

10

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The current epidemiological data on radiation carcinogenesis in humans and the biological mechanisms are discussed in this review. It was concluded that a threshold dose for radiation carcinogenesis above order of 1 mSv is an unlikely possibility. The prudent approach in procedures required for justification and optimization should be considered in practice of radiography.