著者

呉 沙 古谷 栄光

出版者

一般社団法人 システム制御情報学会

雑誌

システム制御情報学会論文誌 (ISSN:13425668)

巻号頁・発行日

vol.29, no.6, pp.258-265, 2016-06-10 (Released:2016-09-15)

参考文献数

17

被引用文献数

2

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In critically ill patients suffering from hyperglycemia it has been recently shown that mortality and morbidity can be reduced by keeping glycemia within 80-110 mg/dL (4.4-6.1 mmol/L). However, maintaining blood glucose (BG) levels within such range is difficult because of the time variability in insulin sensitivity through the patient recovery. In this study, we introduce a nonlinear model predictive control algorithm using a time-invariant model of glucose-insulin metabolism for the eventual development of a control system that regulates BG levels of critically ill patients. Simulation results using virtual patients with time-varying insulin sensitivity show that BG levels can be kept 58.3% within the 80-110 mg/dL range with only 1.4% of BG levels decreasing below 80 mg/dL (4.4 mmol/L), which demonstrates the safety of the present control algorithm.