著者

河津 優太 土田 潤 安藤 宗司 平川 晃弘 寒水 孝司

出版者

日本計量生物学会

雑誌

計量生物学 (ISSN:09184430)

巻号頁・発行日

vol.42, no.1, pp.55-64, 2021 (Released:2022-04-22)

参考文献数

11

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Phase I oncology clinical trials are designed to evaluate the safety of test drug/s and to determine the recommended dose for subsequent trials. However, the method to determine the required number of participants (sample size) has not been sufficiently developed for these dose-finding studies. The usual approach involves time-consuming calculations using numerical experiments to establish the required sample size that will allow the determination of accurate recommended dose of the test drug/s. In this study, we propose a time-saving method to determine the sample size. This method uses an alternative index of the proportion to accurately select the recommended dose. In the numerical experiments, we compared the performances (sample size, proportion of correctly selected recommended dose, and calculation time for the determination of sample size) of the proposed method with those of the conventional method. The sample size and the proportion of correctly selected recommended dose, determined by the proposed method, were slightly different from those calculated using the conventional method. The calculation time of the proposed method was consistently shorter than that of the conventional method. These results suggest that the proposed method can be used to roughly estimate the sample size of phase I oncology studies.

著者

土田 潤 伊東 聰 藤澤 智光 矢川 元基

出版者

一般社団法人日本機械学会

雑誌

日本機械学會論文集. B編 (ISSN:03875016)

巻号頁・発行日

vol.69, no.678, pp.280-285, 2003-02-25

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The sounding mechanism in air-reed instruments is investigated based on the computational fluid dynamics. While previous studies have assumed a sound source based on acoustic theory, the authors attempt in the present study to elucidate exactly the source of sound as an essential factor defining the timbre of musical instruments. To deal with the large computational grids required to capture minute changes in pressure, the Hitachi SR 8000 massively parallel supercomputer is employed for computation. The computational results are consistent with Brown's experimental equation, and new frequency component revealed only in this three-dimensional analysis is identified, attributed to the harmonics of the air jet.

著者

土田 潤 宿久 洋

出版者

情報・システム研究機構統計数理研究所

雑誌

統計数理 = Proceedings of the Institute of Statistical Mathematics (ISSN:09126112)

巻号頁・発行日

vol.65, no.2, pp.271-286, 2017-12