著者
飯森 隆昌 村井 安 脇坂 康尋 大塚 晏央 大内 章吉 児玉 佳男 大石 武
出版者
The Pharmaceutical Society of Japan
雑誌
Chemical and Pharmaceutical Bulletin (ISSN:00092363)
巻号頁・発行日
vol.41, no.4, pp.775-777, 1993-04-15 (Released:2008-03-31)
参考文献数
14
被引用文献数
2 8

Conformational restrictions of sangivamycin (1) could be achieved by the use of the gauche effect of the substitutents on the ribofranose moiety. The conformational deviations obtained by this method were found to nicely correlate with the inhibitory activity of PKC.