著者

森永 直樹 内ヶ島 美岐子 Mohammad Abdur RAHIM 大西 一聡 高橋 和文 小杉 善雄

出版者

公益社団法人 日本化学会

雑誌

日本化学会誌(化学と工業化学) (ISSN:03694577)

巻号頁・発行日

vol.2002, no.3, pp.467-469, 2002 (Released:2004-03-05)

参考文献数

15

被引用文献数

2

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The carboxylation of m-aminophenol with potassium hydrogencarbonate in aqueous solutions has been studied kinetically. The formation of 4-hydroxyanthranilic acid (4HAA) has been found for the first time in the carboxylation of m-aminophenol which gives only p-aminosalicylic acid (pAS) in the usual Kolbe-Schmitt reaction. Since 4HAA was easily decarboxylated, the product was removed from the reaction mixture after the carboxylation for 1 h at 60 °C. This method was repeated three times and 4HAA was obtained as a major product in 30.2% yield.