著者

天児 由佳

出版者

公益社団法人 有機合成化学協会

雑誌

有機合成化学協会誌 (ISSN:00379980)

巻号頁・発行日

vol.76, no.4, pp.358-359, 2018-04-01 (Released:2018-04-06)

参考文献数

11

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PROTACs (proteolysis-targeting chimeric molecules), which comprise a target protein ligand, an E3 ubiquitin ligase ligand and a linker, induce selective degradation of the target protein by recruiting the E3 ubiquitin ligase. This approach is attracting attention as an alternative of traditional inhibitor-based therapeutics by small molecules. This review briefly summarizes the development and advances of PROTACs.