著者
天児 由佳
出版者
公益社団法人 有機合成化学協会
雑誌
有機合成化学協会誌 (ISSN:00379980)
巻号頁・発行日
vol.76, no.4, pp.358-359, 2018-04-01 (Released:2018-04-06)
参考文献数
11

PROTACs (proteolysis-targeting chimeric molecules), which comprise a target protein ligand, an E3 ubiquitin ligase ligand and a linker, induce selective degradation of the target protein by recruiting the E3 ubiquitin ligase. This approach is attracting attention as an alternative of traditional inhibitor-based therapeutics by small molecules. This review briefly summarizes the development and advances of PROTACs.