著者

寺田 安一 伊藤 均

出版者

公益社団法人 日本薬理学会

雑誌

日本薬理学雑誌 (ISSN:00155691)

巻号頁・発行日

vol.66, no.3, pp.304-315, 1970 (Released:2007-03-29)

参考文献数

25

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The toxic agent involved in the extract of rotten short-neck clam was searched by us chemically and pharmacologically, The results are as follows: 1) Tyramine, putrescine, agmatine and cadaverine were produced in it, though histamine was not. 2)Choline was produced in it. Its amount was 1.70-4.25 mg/g. 3) The antagonistic manner of atropine or benadryl against to the intestinal contraction of a guinea pig caused from the serosal side in vitro by this extract was similar to that against to the choline action. 4) The rotten extract induced the contraction of a guinea pig alimentary tract from its mucosal side in vivo. 5) Choline induced the contraction of a guinea pig alimentary tract from its mucowl side in vivo with the concentration of 1.70-4.25 mg/ml. 6) The quantity of feces excreted from a guinea pig increased without delay after oral administration of 5 ml of that rotten extract, but returned to the normal quantity in 5 hours. From the above data, the agent of the food poisoning caused by rotten short-neck clam is considered to be choline in it.