著者

山下 純一 安本 三治 橋本 貞夫

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.31, no.11, pp.3872-3877, 1983-11-25 (Released:2008-03-31)

参考文献数

19

被引用文献数

3 4

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The mechanism of the condensation of 5-fluorouracil and 2-acetoxytetrahydrofuran (3), giving 1-(tetrahydro-2-furyl)-5-fluorouracil, was studied. An equilibrium between 2-acetoxytetrahydrofuran (3) and 2, 3-dihydrofuran (4) was observed at 120-170°C in dimethylformamide. It was found by the use of 1, 3-dideuterio-5-fluorouracil that the condensation of 5-fluorouracil with 3 occurred both by direct substitution and by the formation of 4 from 3 followed by addition of the uracil to it. The contribution of the latter path increased with increase of the reaction temperature.

著者

山下 純一

出版者

現代数学社

雑誌

現代数学 (ISSN:21876495)

巻号頁・発行日

vol.48, no.4, pp.86-90, 2015-04

著者

トニー・ロスマン[ほか]著 山下純一訳編

出版者

現代数学社

巻号頁・発行日

1990