- 著者
- 伊関 克彦 間瀬 俊明 岡崎 徳二 柴崎 正勝 池上 四郎
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.31, no.12, pp.4448-4455, 1983-12-25 (Released:2008-03-31)
- 参考文献数
- 21
- 被引用文献数
- 7 9
Biologically interesting 9 (O)-methano-△6-prostaglandin I1 (9 (O)-methano-△6-PGI1), a chemically stable analog of prostacyclin (PGI2), was efficiently synthesized from 1, 3-cyclooctadiene with high stereo- and regiochemical control. In all three biological test systems examined, 9 (O)-methano-△6-PGI1 was found to be considerably less active than prostaglandin E1 (PGE1).