著者

渡辺 一弘 岩田 一幸 丹代 優香 西澤 信 山岸 喬 吉沢 逸雄

出版者

公益社団法人日本薬学会

雑誌

衛生化学 (ISSN:0013273X)

巻号頁・発行日

vol.38, no.3, pp.258-262, 1992-06-30

被引用文献数

11

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The effects of soluble sodium alginate of average molecular weight (A.M.W.), 1×10^4 (AG-1), 5×10^4 (AG-5) or 1×10^5 (AG-10) on the excretion of ^3H-labeled cholesterol, Trp-P-1 and aflatoxin B_1 in rat were compared with those of commercially available sodium alginate (A.M.W. : 2.7×10^6,AG-270) and polydextrose. In rats administered ^3H-cholesterol, the simultaneous administration of AG-10 or AG-270 (100mg/kg) significantly increased the amount of isotope excreted in feces. The administration of AG-5 or AG-10 (1000 mg/kg) after the administration of the tested compounds increased the amounts isotope excretion into feces, and decreased significantly those into urine. The administration of AG-1,however, showed no effect. These results indicate that AG-5 and AG-10 exhibited the same accelerating effects on the excretion of the tested compounds as AG-270.