著者

北村 二朗 嶋 みな子 平塚 京子 浅野 進吾

出版者

公益社団法人日本薬学会

雑誌

藥學雜誌 (ISSN:00316903)

巻号頁・発行日

vol.96, no.6, pp.732-736, 1976-06-25

---

Examinations were made on the action of anhydromevalonic acid lactone, which inhibits incorporation of mevalonic acid into cholesterol in the cell-free system of rat liver, on microorganisms was studied. Microorganisms examined were mevalonic acid-requiring Lactobacillus acidphilus ATCC 4963 and L. heterohiochii H-1,and Saccharomyces cerevisiae and S. carlsbergensis ATCC 9080 which do not require mevalonic acid and have the ability to synthesize sterol. In the presence of 0.1 μg/ml of mevalonic acid, L. acidophilus required ca. 15 mg/ml of anhydromevalonic acid lactone for 50% suppression and 25 mg/ml for 100% suppression. In the presence of 1.0 or 4.0 μg/ml of mevalonic acid, L. heterohiochii required 0.5 and 20 mg/ml, respectively, of anhydromevalonic acid lactone. In the presence of 15 and 20 mg/ml of anhydromevalonic acid lactone the growth of S. cerevisiae and S. carlsbergensis was completely inhibited. However, there was hardly any effect on the sterol content per unit cell weight.